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ISSN 1001-5256 (Print)
ISSN 2097-3497 (Online)
CN 22-1108/R
Volume 37 Issue 12
Dec.  2021
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Article Navigation >  Journal of Clinical Hepatology  > 2021  >  37(12): 2986-2989

Role of leukemia inhibitory factor in pancreatic ductal adenocarcinoma

DOI: 10.3969/j.issn.1001-5256.2021.12.053
  • 1.

    The First Clinical Medical College of Shanxi Medical University, Taiyuan 030000, China

  • 2.

    Department of General Surgery, The First Hospital of Shanxi Medical University, Taiyuan 030000, China

  • Received Date: 2021-04-21
  • Accepted Date: 2021-05-13
  • Published Date: 2021-12-20
    Abstract
  • Pancreatic ductal adenocarcinoma is a highly invasive malignant tumor of the digestive system with an extremely poor prognosis. Leukemia inhibitory factor is an important member of the interleukin-6 family and can regulate multiple physiological processes such as cell differentiation, growth, and renewing. This article reviews the mechanism of action of leukemia inhibitory factor in pancreatic ductal adenocarcinoma and the research advances in leukocyte inhibitory factor-targeted therapy based on literature evidence, and the analysis shows that leukemia inhibitory factor plays an important role in the progression, immune escape, and chemotherapy resistance of pancreatic ductal adenocarcinoma and may gradually become a potential biomarker and therapeutic target for pancreatic ductal adenocarcinoma.

     

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