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《亚太地区慢性乙型肝炎管理共识:2012年更新版》解读:治疗策略、耐药处理和无创肝纤维化评估

樊蓉 梁携儿 孙剑 侯金林

吴剑华, 阮清发, 林立, 马晓军. 慢性乙肝患者血清病毒载量、肝组织病毒抗原表达及炎症分级的关系[J]. 临床肝胆病杂志, 2006, 22(1): 33-34.
引用本文: 吴剑华, 阮清发, 林立, 马晓军. 慢性乙肝患者血清病毒载量、肝组织病毒抗原表达及炎症分级的关系[J]. 临床肝胆病杂志, 2006, 22(1): 33-34.
Wu JianHua, Ruan QingFa, Lin Li, Ma XiaoJun. The relationship of serum HBVDNA levels and the expression of HBV antigen and the inflammation grade in liver tissues in the patients with chronic hepatitis B[J]. J Clin Hepatol, 2006, 22(1): 33-34.
Citation: Wu JianHua, Ruan QingFa, Lin Li, Ma XiaoJun. The relationship of serum HBVDNA levels and the expression of HBV antigen and the inflammation grade in liver tissues in the patients with chronic hepatitis B[J]. J Clin Hepatol, 2006, 22(1): 33-34.

《亚太地区慢性乙型肝炎管理共识:2012年更新版》解读:治疗策略、耐药处理和无创肝纤维化评估

详细信息
  • 中图分类号: R512.62

Explanation of the “Asian-Pacific consensus statement on the management of chronic hepatitis B: A 2012 update”: Treatment strategy, resistance management and non-invasive evalution of liver fibrosis

  • 摘要: <正>2012年2月18日,亚太肝脏研究学会(APASL)在台湾召开的亚太肝脏病年会上发布了备受关注的《亚太地区慢性乙型肝炎管理共识:2012年更新版》(以下简称2012年共识)[1],这是自2000年发布第一版共识以来,历经2003、2005和2008年3次更新和修订,时隔4年第5次发布修订的共识意见。2012年共识紧密结合亚太地区慢性乙型肝炎(CHB)的流行病学特点及医疗现状,总结

     

  • [1]Liaw YF, Kao JH, Piratvisuth T, et al.Asian-Pacific Con-sensus statement on the management of chronic hepatitis B:A 2012 update[J].Hepatol Int, 2012, 6 (3) :531-561.
    [2]European Association For The Study Of The Liver.EASL Clin-ical Practice Guidelines:Management of chronic hepatitis B[J].J Hepatol, 2009, 50 (2) :227-242.
    [3] Lok ASF, McMahon BJ. Chronic hepatitis B: Update 2009[J]. Hepatology, 2009, 50 (3) : 661-662.
    [4]Sung JJY, Tsoi KKF, Wong VWS, et al.Meta-analysis:treat-ment of hepatitis B infection reduces risk of hepatocellular carcino-ma[J].Aliment Pharmacol Ther, 2008, 28 (9) :1067-1077.
    [5]Chu CM, Liaw YF.Chronic hepatitis B virus infection ac-quired in childhood:special emphasis on prognostic andtherapeutic implication of delayed HBeAg seroconversion[J].J Viral Hepat, 2007, 14 (3) :147-152.
    [6] Lai M, Hyatt BJ, Nasser I, et al. The clinical significance of persistently normal ALT in chronic hepatitis B infection[J]. J Hepatol, 2007, 47 (6) : 760-767.
    [7]Liaw YF, Jia JD, Chan HLY, et al.Shorter durations and lowerdoses of peginterferon alfa-2a are associated with inferior hepati-tis B e antigen seroconversion rates in hepatitis B virus genotypesB or C[J].Hepatology, 2011, 54 (5) :1591-1599.
    [8]Sonneveld MJ, Wong VWS, Woltman AM, et al.Polymor-phisms near IL28B and serologic response to peginterferon inHBeAg-positive patients with chronic hepatitis B[J].Gas-troenterology, 2012, 142 (3) :513-520.e1.
    [9]Buster EHCJ, Hansen BE, Lau GKK, et al.Factors that pre-dict response of patients with hepatitis B e antigen–positivechronic hepatitis B to peginterferon-alfa[J].Gastroenterol-ogy, 2009, 137 (6) :2002-2009.
    [10]Degos F, Perez P, Roche B, et al.Diagnostic accuracy of Fi-broScan and comparison to liver fibrosis biomarkers in chronicviral hepatitis:a multicenter prospective study (the FIBROS-TIC study) [J].J Hepatol, 2010, 53 (6) :1013-1021.
    [11] Marcellin P, Ziol M, Bedossa P, et al. Non-invasive assessment of liver fibrosis by stiffness measurement in patients with chronic hepatitis B[J]. Liver Int, 2009, 29 (2) : 242-247.
    [12]Chan HL, Wong GL, Choi PC, et al.Alanine aminotrans-ferase-based algorithms of liver stiffness measurement bytransient elastography (Fibroscan) for liver fibrosis in chron-ic hepatitis B.[J].J Viral Hepat, 2009, 16 (1) :36-44.
    [13] Sporea I, Sirli RL, Deleanu A, et al. Acoustic radiation force impulse elastography as compared to transient elastography and liver biopsy in patients with chronic hepatopathies[J]. Ultraschall Med, 2011, 32 (Suppl 1) : S46-S52.
    [14]Wong GL, Wong VW, Choi PC, et al.Development of a non-invasive algorithm with transient elastography (Fibroscan (R) ) and serum test formula for advanced liver fibrosis inchronic hepatitis B[J].Aliment Pharmacol Ther, 2010, 31 (10) :1095-1103.
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  • 出版日期:  2012-07-20
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