胆囊癌的靶向治疗研究进展

杜丽文; 刘建生

doi:10.3969/j.issn.1001-5256.2023.12.032

胆囊癌的靶向治疗研究进展

DOI: 10.3969/j.issn.1001-5256.2023.12.032

杜丽文¹,
刘建生^2, , ,

1.
山西医科大学，太原 030001
2.
山西医科大学第一医院肝胆胰外科，太原 030001

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：杜丽文负责拟定写作思路，资料分析，撰写论文；刘建生负责修改论文并最后定稿。

详细信息

通信作者:
刘建生， 147542533@qq.com （ORCID： 0000-0002-6038-2560）

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出版历程
- 收稿日期: 2023-03-19
- 录用日期: 2023-05-12
- 出版日期: 2023-12-12

Research advances in targeted therapy for gallbladder carcinoma

Liwen DU¹,
Jiansheng LIU^{2
, ,
,}

1.
Shanxi Medical University，Taiyuan，030001，China
2.
Department of Hepatobiliary and Pancreatic Surgery，The First Hospital of Shanxi Medical University，Taiyuan 030001，China

More Information

Corresponding author: LIU Jiansheng， 147542533@qq.com （ORCID： 0000-0002-6038-2560）

摘要

摘要: 胆囊癌（GBC）是一种预后极差的恶性肿瘤，外科手术是目前最有效的治疗手段。但由于该疾病早期缺乏典型症状，患者在确诊时大多已进展至中晚期，失去根治性手术切除机会。在现有的辅助治疗方法中，靶向治疗是一种特异性较高且副作用较小的治疗手段，对多种癌症的预后产生了积极的效果。本文通过研究GBC靶向治疗的最新进展，对GBC靶向治疗的研究现状、潜在靶点及靶向药物研究进行综述，以期为GBC患者的临床治疗提供参考。
- 胆囊肿瘤 /
- 信号传导 /
- 治疗学
Abstract: Gallbladder carcinoma （GBC） is a type of malignant tumor with an extremely poor prognosis， and at present， surgical operation is the most effective treatment method for this disease. Unfortunately， due to a lack of typical symptoms in the early stage， most patients have progressed to the advanced stage at the time of confirmed diagnosis and lost the opportunity for radical surgery. Among the currently available adjuvant treatments， targeted therapy has higher specificity and fewer side effects and has improved the prognosis of a variety of malignancies. With reference to the latest research advances in targeted therapy for GBC， this article reviews the current research status， potential targets， and targeted medications of targeted therapy for GBC， in order to provide a reference for the clinical treatment of GBC patients.
- Gallbladder Neoplasms /
- Signal Transduction /
- Therapeutics

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