机械力在肝脏类器官形成中的调控作用

王宁; 吕文良

doi:10.3969/j.issn.1001-5256.2023.12.030

机械力在肝脏类器官形成中的调控作用

DOI: 10.3969/j.issn.1001-5256.2023.12.030

王宁,
吕文良^, ,

中国中医科学院广安门医院感染疾病科，北京 100053

基金项目:

国家自然科学基金 (81774282);

国家重点研发计划 (2018YFC1705700);

中国中医科学院科技创新工程 (C12021A00801);

中国中医科学院科技创新工程 (C12021A00802)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：王宁负责起草和修订论文；吕文良负责论文框架设计，终审论文并最后定稿。

详细信息

通信作者:
吕文良， lvwenliang@sohu.com （ORCID： 0000-0002-4552-919X）

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- 被引次数: 0
出版历程
- 收稿日期: 2023-03-24
- 录用日期: 2023-04-19
- 出版日期: 2023-12-12

Regulatory role of mechanical forces in the formation of liver organoids

Ning WANG,
Wenliang LYU^{,
,}

Department of Infectious Diseases，Guang’anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China

Research funding:

National Natural Science Foundation of China (81774282);

National Key Research and Development Program of China (2018YFC1705700);

Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences (C12021A00801);

Science and Technology Innovation Project of the China Academy of Chinese Medical Sciences (C12021A00802)

More Information

Corresponding author: LYU Wenliang， lvwenliang@sohu.com （ORCID： 0000-0002-4552-919X）

摘要

摘要: 近年来，材料科学和技术的不断进步，使得模拟体内器官结构和功能特征的肝脏类器官技术得以建立并发展，除了对传统生物因素的研究，构建具有不同机械线索的微环境来研究力学刺激对肝脏类器官生长的影响也成为研究重点。本文论述肝脏类器官的发展，并对不同性质机械力在肝脏类器官形成过程中的作用进行综述，为体外构建更加复杂有序的肝脏类器官奠定基础，也为理解肝脏类器官形成过程中生物因素和机械因素之间的相互作用提供理想的研究模型。
- 类器官 /
- 肝 /
- 生物因子 /
- 细胞微环境
Abstract: In recent years， the continuous advances in material sciences and techniques have helped with the establishment and development of liver organoids that can simulate the structure and function of organs in vivo. In addition to the research on traditional biological factors， the construction of microenvironments with different mechanical cues to investigate the influence of mechanical stimulation on the growth of liver organoids has also become a research focus. This article first discusses the development of liver organoids and then reviews the influence of mechanical forces of different properties on the formation of liver organoids， so as to lay a foundation for the construction of more complex and ordered liver organoids in vitro and provide ideal research models for understanding the interaction between biological and mechanical factors in the formation of liver organoids.
- Organoids /
- Liver /
- Biological Factors /
- Cellular Microenvironment

HTML全文

图 1 类器官形成过程中涉及不同类型机械力示意图

注： a，诱导培养的类器官和胚胎的局部张力和收缩力的微模式；b，诱导培养类器官流动剪切力的微流控装置；c，不同硬度类器官培养的合成水凝胶。

Figure 1. Schematic diagram of the different types of mechanical forces involved in organoid formation

下载: 全尺寸图片幻灯片

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