机械力在肝脏类器官形成中的调控作用
DOI: 10.3969/j.issn.1001-5256.2023.12.030
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:王宁负责起草和修订论文;吕文良负责论文框架设计,终审论文并最后定稿。
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摘要: 近年来,材料科学和技术的不断进步,使得模拟体内器官结构和功能特征的肝脏类器官技术得以建立并发展,除了对传统生物因素的研究,构建具有不同机械线索的微环境来研究力学刺激对肝脏类器官生长的影响也成为研究重点。本文论述肝脏类器官的发展,并对不同性质机械力在肝脏类器官形成过程中的作用进行综述,为体外构建更加复杂有序的肝脏类器官奠定基础,也为理解肝脏类器官形成过程中生物因素和机械因素之间的相互作用提供理想的研究模型。Abstract: In recent years, the continuous advances in material sciences and techniques have helped with the establishment and development of liver organoids that can simulate the structure and function of organs in vivo. In addition to the research on traditional biological factors, the construction of microenvironments with different mechanical cues to investigate the influence of mechanical stimulation on the growth of liver organoids has also become a research focus. This article first discusses the development of liver organoids and then reviews the influence of mechanical forces of different properties on the formation of liver organoids, so as to lay a foundation for the construction of more complex and ordered liver organoids in vitro and provide ideal research models for understanding the interaction between biological and mechanical factors in the formation of liver organoids.
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Key words:
- Organoids /
- Liver /
- Biological Factors /
- Cellular Microenvironment
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