瘦型非酒精性脂肪性肝病的研究进展

张瑜娟; 周希乔

doi:10.3969/j.issn.1001-5256.2023.12.024

瘦型非酒精性脂肪性肝病的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.12.024

张瑜娟¹,
周希乔^2, , ,

1.
南京中医药大学第一临床医学院，南京 210000
2.
南京中医药大学附属医院内分泌科，南京 210000

基金项目:

江苏省中医药管理局项目 (ZT202105)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张瑜娟负责收集数据，资料分析，撰写论文；周希乔负责拟定写作思路，指导文章并最后定稿。

详细信息

通信作者:
周希乔， zhouxiqiao@njucm.edu.cn （ORCID： 0000-0003-3122-3904）

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出版历程
- 收稿日期: 2023-03-29
- 录用日期: 2023-05-15
- 出版日期: 2023-12-12

Research advances in lean nonalcoholic fatty liver disease

Yujuan ZHANG¹,
Xiqiao ZHOU^{2
, ,
,}

1.
The First Clinical Medical College of Nanjing University of Chinese Medicine，Nanjing 210000，China
2.
Department of Endocrinology，The Affiliated Hospital of Nanjing University of Chinese Medicine，Nanjing 210000，China

Research funding:

Project of Administration of Traditional Chinese Medicine of Jiangsu Province of China (ZT202105)

More Information

Corresponding author: ZHOU Xiqiao， zhouxiqiao@njucm.edu.cn （ORCID： 0000-0003-3122-3904）

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）是目前全球慢性肝病的主要原因，可进展为肝炎、肝纤维化、肝硬化甚至肝细胞癌，虽然肥胖在NAFLD发生中起着关键作用，但越来越多的研究证实NAFLD在瘦型个体中依然存在，且瘦型NAFLD的死亡风险增加、疾病进展加速。因此，瘦型NAFLD也值得仔细评估和随访，但目前有关瘦型NAFLD的病理生理机制仍知之甚少，本文就瘦型NAFLD的病因、诊断、治疗及预后作一综述。
- 非酒精性脂肪性肝病 /
- 体型 /
- 诊断 /
- 治疗学 /
- 危险因素
Abstract: Nonalcoholic fatty liver disease （NAFLD） is currently the main cause of chronic liver disease worldwide， and it can progress to hepatitis， liver fibrosis， liver cirrhosis， and even hepatocellular carcinoma. Although obesity plays a key role in the development of NAFLD， more and more studies have confirmed that NAFLD still exists in lean individuals， and lean NAFLD is associated with an increased risk of death and accelerated disease progression. Therefore， lean NAFLD also deserves careful evaluation and follow-up； however， we still know little about the pathophysiological mechanism of lean NAFLD. This article reviews the etiology， diagnosis， treatment， and prognosis of lean NAFLD.
- Nonalcoholic Fatty Liver Disease /
- Somatotypes /
- Diagnosis /
- Therapeutics /
- Risk Factors

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表 1 瘦型NAFLD发病率总结

Table 1. Summary of incidence rate of lean NAFLD

作者	国家	来源	样本量（例）	瘦型NAFLD 患病率（%）	诊断标准
Zou B等^［3］	美国	NHANES数据库	14 365	9.6	超声
Niriella MA等^［4］	斯里兰卡	社区人群	2 985	4.0	超声
Zeng J等^［5］	中国	社区人群	2 715	5.2	超声
Navarroza AMC 等^［6］	菲律宾	医院体检	663	11.9	超声
Weinberg EM等^［2］	美国	NAFLD患者	3 386	12.8	超声
Naderian M等^［7］	伊朗	社区人群	927	5.93	超声
Younes R等^［8］	意大利	NAFLD患者	1 339	14.4	肝组织活检

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