淀粉样蛋白在肝脏中的生理病理作用
DOI: 10.3969/j.issn.1001-5256.2023.11.031
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:宗也凯负责论文设计,撰写论文;刘江凯参与论文指导。
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摘要: 淀粉样蛋白被用来描述因蛋白质错误折叠而形成的纤维状聚集体,它与一系列淀粉样变性疾病有关。当淀粉样蛋白沉积在肝脏,就会导致肝淀粉样变性,从而诱发相关病理改变影响肝脏正常生理功能,但这一疾病少有报道且临床常常被忽视。本文主要讨论了淀粉样蛋白在肝脏中的生理病理作用及机制,以便于加深对淀粉样蛋白相关疾病的理解并为相关研究和临床治疗提供一定参考。Abstract: Amyloid protein (AP) is used to describe the fibrous aggregates that form when proteins are misfolded, and it is associated with a series of amyloidosis diseases. When AP is deposited in the liver, it will lead to liver amyloidosis, thereby inducing related pathological changes that affect the normal physiological function of the liver; however, this disease is rarely reported and often neglected in clinical practice. This article reviews the physiological and pathological effects and mechanisms of AP in the liver, so as to improve the understanding of AP-related diseases and provide a reference for related research and clinical treatment.
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Key words:
- Amyloid /
- Amyloidosis /
- Liver Diseases /
- Pathologic Processes
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