肿瘤相关巨噬细胞在胆管细胞癌中的作用

韩品盛; 杨龙; 崔涛; 张雅敏

doi:10.3969/j.issn.1001-5256.2023.02.035

肿瘤相关巨噬细胞在胆管细胞癌中的作用

DOI: 10.3969/j.issn.1001-5256.2023.02.035

韩品盛¹,
杨龙²,
崔涛^{3, 4},
张雅敏^2, , ,

1.
天津医科大学临床医学院，天津 300070
2.
天津市第一中心医院肝胆外科，天津 300192
3.
天津药物研究院释药技术与药代动力学国家重点实验室，天津 300000
4.
中国医学科学院药物代谢新技术创新单元，北京 100730

基金项目:

天津市第一中心医院科技基金 (2019CL01);

中国医学科学院医学与健康科技创新工程项目资助 (2019-I2M-5-020);

天津市“项目+团队”重点培养专项(创新类) (XC202030)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：韩品盛负责文献查阅，论文撰写；杨龙、崔涛负责论文修改，研究指导；张雅敏负责研究指导，经费支持。

详细信息

通信作者:
张雅敏，13802122219@163.com (ORCID: 0000-0002-7175-8762)

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出版历程
- 收稿日期: 2022-07-02
- 录用日期: 2022-09-05
- 出版日期: 2023-02-20

Role of tumor-associated macrophages in cholangiocarcinoma

Pinsheng HAN¹,
Long YANG²,
Tao CUI^{3, 4},
Yamin ZHANG^{2
, ,
,}

1.
Clinical Medical College of Tianjin Medical University, Tianjin 300070, China
2.
Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Tianjin 300192, China
3.
State Key Laboratory of Drug Delivery Technology and Pharmacokinetics, Tianjin Institute of Pharmaceutical Research, Tianjin 300000, China
4.
Research Unit for Drug Metabolism, Chinese Academy of Medical Sciences, Beijing 100730, China

Research funding:

Science and Technology Fund of Tianjin First Central Hospital (2019CL01);

CAMS Innovation Fund for Medical Sciences (2019-I2M-5-020);

Tianjin Key Training Project for 'Project + Team' (XC202030)

More Information

Corresponding author: ZHANG Yamin, 13802122219@163.com (ORCID: 0000-0002-7175-8762)

摘要

摘要: 胆管细胞癌(CCA)是一种恶性程度高，侵袭性强，预后极差，且对放化疗不敏感的胆道恶性肿瘤。肿瘤相关巨噬细胞(TAM)是肿瘤微环境中的重要组成部分，CCA细胞通过释放细胞因子的方式，将TAM募集到肿瘤组织中，并将其极化为M2型TAM，并通过辅助免疫逃逸、促进肿瘤细胞增殖、调控血管生成、促进肿瘤转移、介导免疫耐药等多种机制促进CCA进展。TAM作为一种肿瘤免疫治疗的新兴靶点为CCA的靶向治疗提供了新思路。本文将对近年来TAM促进CCA进展的机制和靶向TAM的免疫治疗作一综述。
- 胆管肿瘤 /
- 巨噬细胞 /
- 肿瘤微环境
Abstract: Cholangiocarcinoma (CCA) is a highly malignant biliary tumor with strong invasion and poor prognosis and is insensitive to radiotherapy and chemotherapy. Tumor-associated macrophage (TAM) is an important component of the tumor microenvironment. CCA cells recruit TAM into tumor tissue by releasing cytokines and polarize them into M2 TAM, which promotes the progression of CCA through various mechanisms such as assisting immune escape, promoting tumor cell proliferation, regulating angiogenesis, promoting tumor metastasis, and mediating immune resistance. As an emerging target of tumor immunotherapy, TAM provides new ideas for targeted therapy for CCA. This article reviews the mechanisms of TAM in promoting the progression of CCA and immunotherapy targeting TAM in recent years.
- Bile Duct Neoplasms /
- Macrophages /
- Tumor Microenvironment

HTML全文

图 1 TAM对CCA的作用

Figure 1. Effects of TAM on CCA

下载: 全尺寸图片幻灯片

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