免疫检查点抑制剂相关胆管炎的研究进展

侯昱丞; 赵洪强; 董草儿; 吴广东; 童翾; 李昂; 卢倩; 陈虹; 汤睿

doi:10.3969/j.issn.1001-5256.2023.02.034

免疫检查点抑制剂相关胆管炎的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.02.034

清华大学附属北京清华长庚医院肝胆胰中心，清华大学临床医学院，北京 102218

基金项目:

国家自然科学基金 (81901957)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：汤睿、侯昱丞、赵洪强对研究的思路及设计有关键贡献；董草儿、吴广东、童翾、李昂参与研究文献的汇总与分析；卢倩、陈虹对论文框架给与关键建议与指导；侯昱丞、赵洪强起草文章关键内容。

详细信息

通信作者:
汤睿，tangrui_hs@163.com(ORCID：0000-0003-3118-3842)

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出版历程
- 收稿日期: 2022-07-03
- 录用日期: 2022-08-18
- 出版日期: 2023-02-20

Research advances in immune checkpoint inhibitor-related cholangitis

Hepatobiliary and Pancreatic Center, Tsinghua University Affiliated Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China

Research funding:

National Natural Science Foundation of China (81901957)

More Information

Corresponding author: TANG Rui, tangrui_hs@163.com (ORCID: 0000-0003-3118-3842)

摘要

摘要: 免疫检查点抑制剂开启了肿瘤治疗的新时代，而免疫治疗相关不良事件是制约其临床应用并逐渐引发关注的重要问题。肝脏是较易受累的靶器官之一。随着研究的进展，学者发现除肝细胞外，肝内外胆管也可成为免疫攻击的对象，继发被称为免疫相关胆管炎的病症。本文通过文献汇总，对免疫检查点抑制剂相关胆管炎的研究进展进行综述，旨在初步揭示其临床、病理、影像特点，为临床早期发现，规范治疗及后续研究提供线索。
- 免疫检查点抑制剂 /
- 免疫相关胆管炎 /
- 程序性死亡蛋白-1
Abstract: Immune checkpoint inhibitors (ICIs) have ushered in a new era of tumor treatment; however, immunotherapy-related adverse events are critical issues that restrict the clinical application of ICIs and have attracted wide attention. The liver is one of the target organs that is easily affected. With the progress in research, scholars have found that besides hepatocytes, intrahepatic and extrahepatic bile ducts can also be attacked by the immune system, leading to the disease known as immune-related cholangitis. This article reviews the research advances in ICI-related cholangitis by summarizing related articles, in order to preliminarily reveal its clinical, pathological, and imaging features and provide clues for early identification, standard treatment, and subsequent research.
- Immune Checkpoint Inhibitors /
- Cholangitis /
- Programmed Death-1

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参考文献(41)

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