慢性肝病并发肌肉脂肪变性的研究进展

孙锦涛; 栗凤霞

doi:10.3969/j.issn.1001-5256.2023.02.031

慢性肝病并发肌肉脂肪变性的研究进展

DOI: 10.3969/j.issn.1001-5256.2023.02.031

孙锦涛,
栗凤霞^, ,

山西医科大学第五临床医学院消化内科，太原 030012

基金项目:

山西省医学重点科技项目 (2020XM23)

利益冲突声明：所有作者均声明不存在利益冲突。

作者贡献声明：孙锦涛负责调研整理文献，资料分析，设计论文框架，撰写论文；栗凤霞负责指导撰写文章并最后定稿。

详细信息

通信作者:
栗凤霞，doctorlfx@163.com (ORCID：0000-0002-6712-0491)

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出版历程
- 收稿日期: 2022-07-01
- 录用日期: 2022-08-12
- 出版日期: 2023-02-20

Research advances in myosteatosis in chronic liver diseases

Jintao SUN,
Fengxia LI^{,
,}

Department of Gastroenterology, The Fifth Clinical Medical College of Shanxi Medical University, Taiyuan 030012, China

Research funding:

Shanxi Province Key Medical Science and Technology Project (2020XM23)

More Information

Corresponding author: LI Fengxia, doctorlfx@163.com (ORCID: 0000-0002-6712-0491)

摘要

摘要: 肌肉脂肪变性是营养不良的主要表现形式，是慢性肝病常见的并发症，对肝脏疾病的进展和预后具有负面影响。肌肉脂肪变性暂无诊断金标准，CT为常用的诊断方法。慢性肝病并发肌脂肪变性的机制是多样的，高氨血症、循环中组织蛋白酶D水平升高、胰岛素抵抗、线粒体功能障碍、慢性系统性微炎症等在慢性肝病肌脂肪化中起重要作用，尽早对其进行干预可改善预后。结合国内外研究现状对肌脂肪变性的特点、诊断方法、发病机制、治疗与干预方面进行了综述。
- 肝疾病 /
- 营养不良 /
- 肌肉脂肪化 /
- 病理状态, 体征和症状
Abstract: Myosteatosis is the main manifestation of malnutrition and is a common complication of chronic liver diseases, with a negative impact on the progression and prognosis of liver diseases. There is no gold standard for the diagnosis of myosteatosis, and CT is a commonly used diagnostic method. Myosteatosis in chronic liver diseases has diverse mechanisms, and hyperammonemia, increased cathepsin D level in circulation, insulin resistance, mitochondrial dysfunction, and chronic systemic microinflammation play an important role in myosteatosis. Early intervention of these factors can improve prognosis. With reference to related studies in China and globally, this article reviews the features, diagnostic methods, pathogenesis, treatment, and intervention of myosteatosis.
- Liver Diseases /
- Malnutrition /
- Myosteatosis /
- Pathological Conditions, Signs and Symptoms

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图 1 慢性肝病相关肌脂肪化机制示意图

注：CTSD，组织蛋白酶D；FFA，游离脂肪酸。

Figure 1. Schematic diagram of the mechanism of muscle steatosis associated with chronic liver disease

下载: 全尺寸图片幻灯片

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