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HBV/HCV相关性肝细胞癌抗病毒治疗专家共识

肝细胞癌抗病毒治疗专家组

引用本文:
Citation:

HBV/HCV相关性肝细胞癌抗病毒治疗专家共识

DOI: 10.3969/j.issn.1001-5256.2014.05.002
基金项目: 

国家“十二·五”科技重大专项(2012ZX10002-016); 

详细信息
  • 中图分类号: R512.62;R512.63

Expert consensus on antiviral therapy to hepatitis B/C virus-related hepatocellular carcinoma

Research funding: 

 

  • 摘要:

    <正>(2014年3月29日)1前言乙型肝炎病毒(HBV)和丙型肝炎病毒(HCV)感染在肝细胞癌(HCC)的发生发展中起重要作用。我国近年发布的《慢性乙型肝炎防治指南(2010版)》和《原发性肝癌诊疗规范(2011版)》都强调了肝癌患者抗病毒治疗的重要性,《丙型肝炎防治指南(2004版)》也注意到抗病毒治疗可延缓HCC的发生。目

     

  • [1] Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association.Recommendation on antiviral therapy to hepatitis B/C virus related hepatocellular carcinoma[J].Chin J Hepatol, 2013, 21 (2) :96-100. (in Chinese) 中华医学会肝病学分会肝癌学组.HBV/HCV相关性肝细胞癌抗病毒治疗专家建议[J].中华肝脏病杂志, 2013, 21 (2) :96-100.
    [2]EL-SERAG HB.Epidemiology of viral hepatitis and hepatocellular carcinoma[J].Gastroenterology, 2012, 142 (6) :1264-1273.
    [3]WU JC, HUANG YH, CHAU GY, et al.Risk factors for early and late recurrence in hepatitis B-related hepatocellular carcinoma[J].J Hepatol, 2009, 51 (5) :890-897.
    [4] European Association for the Study of the Liver.EASL Clinical Practice Guidelines:management of hepatitis C virus infection[J].J Hepatol, 2011, 55 (2) :245-264.
    [5]CHANG TT, LIAW YF, WU SS, et al.Long-term entecavir therapy results in the reversal of fibrosis/cirrhosis and continued histological improvement in patients with chronic hepatitis B[J].Hepatology, 2010, 52 (3) :886-893.
    [6] SUN CA, WU DM, LIN CC, et al.Incidence and cofactors of hepatitis C virus-related hepatocellular carcinoma:a prospective study of 12, 008 men in Taiwan[J].Am J Epidemiol, 2003, 157 (8) :674-682.
    [7] CHEN CJ, YANG HI, SU J, et al.Risk of hepatocellular carcinoma across a biological gradient of serum hepatitis B virus DNA level[J].JAMA, 2006, 295 (1) :65-73.
    [8]XU B, HU DC, ROSENBERG DM, et al.Chronic hepatitis B:a long-term retrospective cohort study of disease progression in Shanghai, China[J].J Gastroenterol Hepatol, 2003, 18 (12) :1345-1352.
    [9] LAI CL, YUEN MF.Prevention of hepatitis B virus-related hepatocellular carcinoma with antiviral therapy[J].Hepatology, 2013, 57 (1) :399-408.
    [10] KIMER N, DAHL EK, GLUUD LL, et al.Antiviral therapy for prevention of hepatocellular carcinoma in chronic hepatitis C:systematic review and meta-analysis of randomized controlled trials[J].BMJ Open, 2012, 2 (5) :e001313.
    [11]European Association for the Study of the Liver.EASL Clinical Practice Guidelines:management of chronic hepatitis B virus infection[J].J Hepatol, 2012, 57 (1) :167-185.
    [12] GHANY MG, STRADER DB, THOMAS DL, et al.Diagnosis, management, and treatment of hepatitis C:an update[J].Hepatology, 2009, 49 (4) :1335-1374.
    [13]GHANY MG, NELSON DR, STRADER DB, et al.An update on treatment of genotype 1 chronic hepatitis C virus infection:2011Practice Guideline by the American Association for the Study of Liver Diseases[J].Hepatology, 2011, 54 (4) :1433-1444.
    [14]LOK AS, MCMAHON BJ.Chronic hepatitis B[J].Hepatology, 2007, 45 (2) :507-539.
    [15]LIAW YF, KAO JH, PIRATVISUTH T, et al.Asian-Pacific consensus statement on the management of chronic hepatitis B:a 2012update[J].Hepatol Int, 2012, 6:531-561.
    [16]OMATA M, KANDA T, YU ML, et al.APASL consensus statements and management algorithms for hepatitis C virus infection[J].Hepatol Int, 2012, 6:409-435.
    [17] 中华医学会肝病学分会, 中华医学会感染病分会.慢性乙型肝炎防治指南 (2010年版) [J].中华内科杂志, 2011, 50 (2) :168-179.
    [18]中华医学会肝病学分会、中华医学会传染病与寄生虫病学分会.丙型肝炎防治指南[J].中华内科杂志, 2004, 43 (7) :551-555.
    [19]KODA M, NAGAHARA T, MATONO T, et al.Nucleotide analogs for patients with HBV-related hepatocellular carcinoma increase the survival rate through improved liver function[J].Inter Med, 2009, 48 (1) :11-17.
    [20] WONG JS, WONG GL, TSOI KK, et al.Meta-analysis:the efficacy of anti-viral therapy in prevention of recurrence after curative treatment of chronic hepatitis B-related hepatocellular carcinoma[J].Aliment Pharmacol Ther, 2011, 33 (10) :1104-1112.
    [21] WU CY, CHEN YJ, HO HJ, et al.Association between nucleoside analogues and risk of hepatitis B virus-related hepatocellular carcinoma recurrence following liver resection[J].JAMA, 2012, 308 (18) :1906-1914.
    [22]LI N, LAI EC, SHI J, et al.A comparative study of antiviral therapy after resection of hepatocellular carcinoma in the immune-active phase of hepatitis B virus infection[J].Ann Surg Oncol, 2010, 17 (1) :1795-1805.
    [23] JANG JW, CHOI JY, BAE SH, et al.A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization[J].Hepatology, 2006, 43 (2) :233-240.
    [24]XIA F, LAI EC, LAU WY, et al.High serum hyaluronic acid and HBV viral load are main prognostic factors of local recurrence after complete radiofrequency ablation of hepatitis B-related small hepatocellular carcinoma[J].Ann Surg Oncol, 2012, 19 (4) :1284-1291.
    [25]SUN HC, TANG ZY, WANG L, et al.Postoperative interferon alpha treatment postponed recurrence and improved overall survival in patients after curative resection of HBV-related hepatocellular carcinoma:a randomized clinical trial[J].J Cancer Res Clin Oncol, 2006, 132 (7) :458-465.
    [26]LO CM, LIU CL, CHAN SC, et al.A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma[J].Ann Surg, 2007, 245 (6) :831-842.
    [27] CHEN CJ, YANG HI, ILOEJE UH, et al.Hepatitis B virus DNA levels and outcomes in chronic hepatitis B[J].Hepatology, 2009, 49 (5 Suppl) :s72-s84.
    [28] HUNG IF, POON RT, LAI CL, et al.Recurrence of hepatitis Brelated hepatocellular carcinoma is associated with high viral load at the time of resection[J].Am J Gastroenterol, 2008, 103 (7) :1663-1673.
    [29] HUANG Y, WANG Z, AN S, et al.Role of hepatitis B virus genotypes and quantitative HBV DNA in metastasis and recurrence of hepatocellular carcinoma[J].J Med Virol, 2008, 80 (4) :591-597.
    [30]KIM YS, LIM HK, RHIM H, et al.Ten-year outcomes of percutaneous radiofrequency ablation as first-line therapy of early hepatocellular carcinoma:Analysis of prognostic factors[J].J Hepatol, 2013, 58 (1) :89-97.
    [31] HUI CK, BOWDEN S, JACKSON K, et al.Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotherapy[J].Blood, 2005, 105 (6) :2616-2617.
    [32]CAI XR, HUANG CY, ZHOU HH, et al.The relationship between the level of HBV DNA in serum and the recentlyoperative effect of primary hepatocarcinoma with HBV infection[J].J Hepatobiliary Surg, 2007, 15 (3) :175-177. (in Chinese) 蔡欣然, 黄长玉, 周浩辉, 等.HBV感染肝癌患者血清HBVDNA水平与手术近期疗效的关系[J].肝胆外科杂志, 2007, 15 (3) :175-177.
    [33]JANG JW, CHOI JY, BAE SH, et al.Transarterial chemolipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinoma[J].J Hepatol, 2004, 41 (3) :427-435.
    [34] LAO XM, WANG D, SHI M, et al.Changes in hepatitis B virus DNA levels and liver function after transcatheter arterial chemoembolization of hepatocellular carcinoma[J].Hepatol Res, 2011, 41 (6) :553-563.
    [35]KIM JH, PARK JW, KIM TH, et al.Hepatitis B virus reactivation after three-dimensional conformal radiotherapy in patients with hepatitis B virus-related hepatocellular carcinoma[J].Int J Radiat Oncol Biol Phys, 2007, 69 (3) :813-819.
    [36] YEO W, LAM KC, ZEE B, et al.Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy[J].Ann Oncol, 2004, 15 (11) :1661-1666.
    [37] NAGAMATSU H, ITANO S, NAGAOKA S, et al.Prophylactic lamivudine administration prevents exacerbation of liver damage in HBe antigen positive patients with hepatocellular carcinoma undergoing transhepatic arterial infusion chemotherapy[J].Am J Gastroenterol, 2004, 99 (12) :2369-2375.
    [38]PENG JW, LIN GN, XIAO JJ, et al.Hepatitis B virus reactivation in hepatocellular carcinoma patients undergoing transcatheter arterial chemoembolization therapy[J].Asia Pac J Clin Oncol, 2012, 8 (4) :356-361.
    [39]YIN JH, LI N, HAN YF, et al.Effect of antiviral treatment with nucleotide/nucleoside analogs on postoperative prognosis of hepatitis B virus-related hepatocellular carcinoma:a two-stage longitudinal clinical study[J].J Clin Oncol, 2013, 31 (29) :3647-3655.
    [40]HUANG G, YANG Y, SHEN F, et al.Early viral suppression predicts good postoperative survivals in patients with hepatocellular carcinoma with a high baseline HBV DNA load[J].Ann Surg Oncol, 2013, 20 (5) :1482-1490.
    [41]HUANG G, LAI EC, LAU WY, et al.Posthepatectomy HBV reactivation in hepatitis B-related hepatocellular carcinoma influences postoperative survival in patients with preoperative low HBV-DNA levels[J].Ann Surg, 2013, 257 (3) :490-505.
    [42]DAN JQ, ZHANG YJ, HUANG JT, et al.Hepatitis B virus reactivation after radiofrequency ablation or hepatic resection for HBV-related small hepatocellular carcinoma:a retrospective study[J].Eur J Surg Oncol, 2013, 39 (8) :865-872.
    [43]TANIMOTO Y, TASHIRO H, AIKATA H, et al.Impact of pegylated interferon therapy on outcomes of patients with hepatitis C virus-related hepatocellular carcinoma after curative hepatic resection[J].Ann Surg Oncol, 2012, 19 (2) :418-425.
    [44] HAGIHARA H, NOUSO K, KOBAYASHI Y, et al.Effect of pegylated interferon therapy on intrahepatic recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma[J].Int J Clin Oncol, 2011, 16 (3) :210-220.
    [45]SINGAL AK, SINGH A, JAGANMOHAN S, et al.Antiviral therapy reduces risk of hepatocellular carcinoma in patients with hepatitis C virus-related cirrhosis[J].Clin Gastroenterol Hepatol, 2010, 8 (2) :192-199.
    [46]MIYAKE Y, TAKAKI A, IWASAKI Y, et al.Meta-analysis:interferon-alpha prevents the recurrence after curative treatment of hepatitis C virus-related hepatocellular carcinoma[J].J Viral Hepat, 2010, 17 (4) :287-292.
    [47]ZHANG CH, XU GL, JIA WD, et al.Effects of interferon alpha treatment on recurrence and survival after complete resection or ablation of hepatocellular carcinoma:a meta-analysis of randomized controlled trials[J].Int J Cancer, 2009, 124 (12) :2982-2988.
    [48] BREITENSTEIN S, DIMITROULIS D, PETROWSKY H, et al.Systematic review and meta-analysis of interferon after curative treatment of hepatocellular carcinoma in patients with viral hepatitis[J].Br J Surg, 2009, 96 (9) :975-981.
    [49] WATT K, VELDT B, CHARLTON M.A practical guide to the management of HCV infection following liver transplantation[J].Am J Transplant, 2009, 9 (8) :1707-1713.
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