乳酸在代谢相关脂肪性肝病中的调控作用及其机制

孙雯可; 伞吉爽; 杨建成

doi:10.12449/JCH260829

乳酸在代谢相关脂肪性肝病中的调控作用及其机制

DOI: 10.12449/JCH260829

沈阳农业大学动物科学与医学学院，沈阳 110000

基金项目:

国家自然科学基金面上项目 (32573324);

国家自然科学基金面上项目 (32272965)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：孙雯可负责资料查找，撰写和修改论文；伞吉爽负责校对论文；杨建成负责指导修改论文并最终定稿。

详细信息

通信作者:
杨建成， syndyjc@syau.edu.cn （ORCID： 0000-0002-4509-0893）

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出版历程
- 收稿日期: 2025-12-10
- 录用日期: 2026-02-09
- 出版日期: 2026-08-25

Regulatory role and mechanism of lactate in metabolic dysfunction-associated fatty liver disease

College of Animal Science and Veterinary Medicine，Shenyang Agricultural University，Shenyang 110000，China

Research funding:

General Project of National Natural Science Foundation of China (32573324);

General Project of National Natural Science Foundation of China (32272965)

More Information

Corresponding author: Yang Jiancheng， syndyjc@syau.edu.cn （ORCID： 0000-0002-4509-0893）

摘要

摘要: 代谢相关脂肪性肝病（MAFLD）是一种在全球范围内患病率持续处于较高水平的慢性肝脏疾病，其发病机制涉及多系统代谢紊乱，目前尚未形成完整的调控理论体系。乳酸曾被认为是糖酵解途径的代谢终末废物，但近年来其作为关键信号分子的生物学功能持续被发掘。乳酸代谢失调与MAFLD发生发展的密切关联，已逐渐成为代谢性肝病领域的研究热点。本文系统介绍了乳酸代谢的核心通路及其调控模式，详细阐述了乳酸参与MAFLD发生发展的整体作用特征，重点评述了乳酸通过蛋白质乳酸化修饰等表观调控机制介导肝脏脂质代谢紊乱、驱动炎症级联反应的分子机制，并简要探讨了乳酸经肠-肝轴调控肝脏代谢稳态的潜在效应，归纳总结了乳酸代谢与MAFLD相关研究的最新进展。本文认为，靶向乳酸代谢通路是深化MAFLD病理生理机制理解的重要切入点，指出乳酸化修饰等非经典调控模式是未来值得重点突破的研究方向，并提出基于乳酸代谢网络开发MAFLD早期诊断标志物与干预靶点具有重要的理论价值与临床转化潜力。
- 代谢相关脂肪性肝病 /
- 乳酸 /
- 代谢 /
- 病理过程
Abstract: Metabolic dysfunction-associated fatty liver disease （MAFLD） is a chronic liver disease with a persistently high prevalence rate worldwide. Its pathogenesis involves metabolic disorders in multiple systems， and there is still a lack of a complete theoretical regulatory framework. Lactate was once regarded as a terminal metabolic waste product of the glycolytic pathway； however， studies in recent years have been exploring its biological functions as a key signaling molecule， and the close association between dysregulated lactate metabolism and the development and progression of MAFLD has gradually become a research hotspot in the field of metabolic liver diseases. This article systematically introduces the core pathways and regulatory patterns of lactate metabolism， elaborates on the overall functional characteristics of lactate in the development and progression of MAFLD， and reviews the molecular mechanisms by which lactate mediates hepatic lipid metabolism disorders and drives inflammatory cascades through epigenetic regulatory mechanisms such as protein lactylation. In addition， it briefly describes the potential effect of lactate in modulating liver metabolic homeostasis via the gut-liver axis and summarizes the latest research advances in lactate metabolism and MAFLD. This article highlights that targeting lactate metabolic pathways is a critical entry point for deepening the understanding of the pathophysiological mechanisms of MAFLD， and it points out that non-canonical regulatory modes represented by lactylation are key breakthrough directions for future research. It also proposes that developing early diagnostic biomarkers and intervention targets for MAFLD based on the lactate metabolic network holds important theoretical value and clinical translation potential.
- Metabolic Dysfunction-Associated Fatty Liver Disease /
- Lactic Acid /
- Metabolism /
- Pathologic Processes

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