中药提取物靶向腺苷酸活化蛋白激酶信号通路防治肝细胞癌的作用机制

曾朔; 胡素芹; 胡洋; 罗磊; 李明彦; 张勤生

doi:10.12449/JCH251030

中药提取物靶向腺苷酸活化蛋白激酶信号通路防治肝细胞癌的作用机制

DOI: 10.12449/JCH251030

曾朔¹,
胡素芹²,
胡洋¹,
罗磊²,
李明彦²,
张勤生^2, , ,

1.
河南中医药大学第二临床医学院，郑州 450002
2.
河南省中医院（河南中医药大学第二附属医院）肝胆脾胃病科，郑州 450002

基金项目:

国家中医药管理局中国中医药科技发展中心联合研究项目 (CXZH202304);

国家自然科学基金 (82305074);

河南省中医药传承与创新人才工程（仲景工程）中医药学科领军人才项目 (Yuwei Zhongyi Han ［2021］ No.08)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：曾朔负责查阅文献，撰写论文；胡素芹、胡洋、罗磊、李明彦负责修改论文；张勤生负责拟定写作思路，指导文章撰写并定稿。

详细信息

通信作者:
张勤生， hnszqs@163.com （ORCID： 0000-0001-5960-0543）

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出版历程
- 收稿日期: 2025-02-16
- 录用日期: 2025-04-11
- 出版日期: 2025-10-25

Mechanism traditional Chinese medicine extract preventing and treating hepatocellular carcinoma by targeting the adenosine monophosphate-activated protein kinase signaling pathway

1.
The Second Clinical Hospital of Henan University of Chinese Medicine，Zhengzhou 450002，China
2.
Department of Hepatology and Spleen-Stomach，Henan Provincial Hospital of Traditional Chinese Medicine （The Second Affiliated Hospital of Henan University of Chinese Medicine），Zhengzhou 450002，China

Research funding:

Joint Research Project of China Center for the Development of Traditional Chinese Medicine Science and Technology of the State Administration of Traditional Chinese Medicine (CXZH202304);

National Natural Science Foundation of China (82305074);

Henan Provincial Traditional Chinese Medicine Inheritance and Innovation Talent Project （Zhongjing Project） Traditional Chinese Medicine Discipline Leading Talent Project (Yuwei Zhongyi Han ［2021］ No.08)

More Information

Corresponding author: ZHANG Qinsheng， hnszqs@163.com （ORCID： 0000-0001-5960-0543）

摘要

摘要: 肝细胞癌（HCC）作为全球癌症发病率和死亡率排名前列的恶性消化道肿瘤，给患者身心健康和社会经济带来巨大的负担。腺苷酸活化蛋白激酶（AMPK）信号通路是细胞的能量代谢调控中心，与HCC细胞的自噬、凋亡、血管生成等生物学活动密切相关，是当前癌症研究的热点。中药富含黄酮类、生物碱类、酚类等天然成分，具有多靶点、多通路、多成分、多层次的特点。通过靶向AMPK信号通路，这些成分可单独使用或联合常规抗癌疗法，对HCC发挥多方面的抗癌作用。本文通过梳理和总结靶向AMPK信号通路防治HCC的中药提取物，以期为中医药治疗HCC的临床应用及药物开发提供理论基础和参考。
- 癌，肝细胞 /
- 中草药 /
- 信号传导 /
- AMP活化蛋白激酶类
Abstract: Hepatocellular carcinoma （HCC） is one of the most common malignant tumors with high incidence and mortality rates worldwide， which brings a huge burden to the physical and mental health and socio-economic life of patients. The adenosine monophosphate-activated protein kinase （AMPK） signaling pathway serves as the regulatory center of cellular energy metabolism and is closely associated with the biological activities of HCC cells， including autophagy， apoptosis， and angiogenesis， and it has become a hot topic in current cancer research. Traditional Chinese medicine drugs are abundant in natural components such as flavonoids， alkaloids， and phenols and have the characteristics of multiple targets， pathways， components， and hierarchies. By targeting the AMPK signaling pathway， these components can be used alone or in combination with conventional antitumor therapies to exert an anti-tumor effect on HCC from various aspects. This article reviews and summarizes the extracts of traditional Chinese medicine that target the AMPK signaling pathway for the prevention and treatment of HCC， in order to provide a theoretical basis and a reference for the clinical application of traditional Chinese medicine in the treatment of HCC and the development of related drugs.
- Carcinoma， Hepatocellular /
- Drugs， Chinese Herbal /
- Signal Transduction /
- AMP-Activated Protein Kinases

HTML全文

注： LC3-Ⅰ，微管相关蛋白1轻链3-Ⅰ；LC3-Ⅱ，微管相关蛋白1轻链3-Ⅱ；Beclin-1，自噬相关蛋白6；p62，sequestosome-1蛋白；Bcl-2，B细胞淋巴瘤-2；Bax，Bcl-2相关X蛋白；caspase，半胱天冬酶；DR5，死亡受体5；CD31，血小板内皮细胞黏附分子-1；VEGF，血管内皮生长因子；M1和M2，肿瘤相关巨噬细胞M1型和M2型；vimentin，波形蛋白；N‐cadherin，神经钙黏蛋白；E-cadherin，E-钙黏蛋白；p21，细胞周期蛋白依赖性激酶抑制剂1A；p27，细胞周期蛋白依赖性激酶抑制剂1B；cyclin，细胞周期蛋白；CDK，细胞周期蛋白依赖性激酶。

图 1 中药提取物激活AMPK信号通路防治HCC的作用机制

Figure 1. Mechanism of action of traditional Chinese medicine extract activating AMPK signaling pathway for the prevention and treatment of HCC

下载: 全尺寸图片幻灯片

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