代谢相关脂肪性肝病与胰腺癌风险关联的流行病学及机制研究进展

张锋; 张一帆; 刘玉兰

doi:10.12449/JCH251026

代谢相关脂肪性肝病与胰腺癌风险关联的流行病学及机制研究进展

DOI: 10.12449/JCH251026

张锋^{1, 2},
张一帆^{1, 2},
刘玉兰^{1, 2, , ,}

1.
北京大学人民医院，消化内科，北京 100044
2.
北京大学人民医院，免疫介导消化疾病研究中心，北京 100044

基金项目:

北京市自然科学基金项目 (7242156);

首都卫生发展科研专项重点攻关项目 (CFH2024-1-4081);

国家自然科学基金面上项目 (82100579);

北京大学人民医院科研发展基金项目 (RDX2022-07)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张锋负责检索文献，撰写文章；张一帆负责审阅并修订关键性论点；刘玉兰负责设计文章框架和审校文章。张锋与张一帆对本文贡献等同，同为第一作者。

详细信息

通信作者:
刘玉兰， liuyulan@pkuph.edu.cn （ORCID： 0000-0001-5026-7828）

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出版历程
- 收稿日期: 2025-03-27
- 录用日期: 2025-04-21
- 出版日期: 2025-10-25

Research advances in the epidemiology and mechanism of the association between metabolic dysfunction-associated fatty liver disease and pancreatic cancer

Feng ZHANG^{1, 2},
Yifan ZHANG^{1, 2},
Yulan LIU^{1, 2
, ,
,}

1.
Department of Gastroenterology, Peking University People’s Hospital，Beijing 100044，China
2.
Clinical Center of Immune-mediated Digestive Diseases, Peking University People’s Hospital，Beijing 100044，China

Research funding:

Beijing Natural Science Foundation (7242156);

Key Research Project of Capital Health Development Scientific Research Special Program (CFH2024-1-4081);

General Project of National Natural Science Foundation of China (82100579);

Peking University People’s Hospital Scientific Research Development Funds (RDX2022-07)

More Information

Corresponding author: LIU Yulan， liuyulan@pkuph.edu.cn （ORCID： 0000-0001-5026-7828）

摘要

摘要: 代谢相关脂肪性肝病（MAFLD）在全球范围内患病率较高，且与多种肝外恶性肿瘤的发生密切相关，其中以胰腺癌的致死率最高。然而，MAFLD和胰腺癌之间的关联机制尚未明确。本文系统介绍了MAFLD与胰腺癌关联的最新流行病学证据，回顾了其发病机制的研究进展，并评述了MAFLD严重程度及高危因素（如非酒精性脂肪性胰腺疾病和导管内乳头状黏液性肿瘤）对胰腺癌风险的影响。文章指出，胰岛素抵抗、脂肪细胞因子及肠道微生态失调等可能是MAFLD促进胰腺癌发生的重要机制；同时认为，当前研究仍存在异质性，未来需依托前瞻性大队列进一步验证因果关系，并探索更有效的分层风险策略。
- 代谢相关脂肪性肝病 /
- 胰腺肿瘤 /
- 危险因素 /
- 病理过程
Abstract: Metabolic dysfunction-associated fatty liver disease （MAFLD） has a relatively high prevalence rate around the world and is closely associated with the development of various extrahepatic malignancies， among which pancreatic cancer exhibits the highest mortality rate. However， the underlying mechanism between MAFLD and pancreatic cancer remains unclear. This article systematically introduces the latest epidemiological evidence of the association between MAFLD and pancreatic cancer， reviews the research advances in pathogenesis， and evaluates the impact of MAFLD severity and high-risk factors （such as nonalcoholic fatty pancreatic disease and intraductal papillary mucinous neoplasm） on the risk of pancreatic cancer. This article points out that insulin resistance， adipokines， and gut dysbiosis may be the key mechanisms of MAFLD promoting the onset of pancreatic cancer， and it also highlights the presence of heterogeneity in current studies. Large-scale prospective cohort studies are needed in the future to further validate the causal relationship and explore more effective strategies for risk stratification.
- Metabolic Dysfunction-Associated Fatty Liver Disease /
- Pancreatic Neoplasms /
- Risk Factors /
- Pathologic Processes

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参考文献(32)

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