原发性胆汁性胆管炎相关肝纤维化中医药治疗进展

张晨阳; 张玮

doi:10.12449/JCH251003

原发性胆汁性胆管炎相关肝纤维化中医药治疗进展

DOI: 10.12449/JCH251003

张晨阳,
张玮^, ,

上海中医药大学附属龙华医院感染科，上海 200032

基金项目:

国家自然科学基金 (81673926)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张晨阳负责文献检索，整理并撰写论文；张玮负责整体构思与写作指导，参与文章内容审阅与修订，完成最终定稿。

详细信息

通信作者:
张玮， lhyyzhangwei@163.com （ORCID： 0009-0005-4211-414X）

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出版历程
- 收稿日期: 2025-07-08
- 录用日期: 2025-08-05
- 出版日期: 2025-10-25

Advances in traditional Chinese medicine treatment of primary biliary cholangitis-related liver fibrosis

Chenyang ZHANG,
Wei ZHANG^{,
,}

Department of Infectious Diseases，Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine，Shanghai 200032，China

Research funding:

National Natural Science Foundation of China (81673926)

More Information

Corresponding author: ZHANG Wei， lhyyzhangwei@163.com （ORCID： 0009-0005-4211-414X）

摘要

摘要: 原发性胆汁性胆管炎（PBC）是一种慢性进行性自身免疫性肝病，易进展为肝纤维化乃至肝硬化。本文总结回顾了中医药联合熊去氧胆酸治疗PBC相关肝纤维化的研究进展。多项研究表明，中西医联合治疗可显著改善PBC相关肝纤维化患者的血清纤维化标志物、无创肝纤维化评分及肝硬度值，且安全性良好，展现出延缓甚至逆转PBC相关肝纤维化进程的潜力。然而，现有证据多基于小样本或短期临床观察，未来仍需开展大样本、高质量的随机对照试验和长期随访研究，并结合现代科技手段深入探索其作用机制，从而进一步验证临床疗效，推动构建循证为基础的中西医结合精准诊疗体系。通过深化研究，中医药有望在PBC相关肝纤维化的治疗领域发挥更为重要的作用。
- 原发性胆汁性胆管炎 /
- 肝纤维化 /
- 抗肝纤维化药（中药） /
- 治疗学
Abstract: Primary biliary cholangitis （PBC） is a chronic progressive autoimmune liver disease that often progresses to liver fibrosis and even liver cirrhosis. This article summarizes and reviews the research advances in the combined use of traditional Chinese medicine （TCM） and ursodeoxycholic acid in the treatment of PBC-related liver fibrosis. Various studies have shown that integrated traditional Chinese and Western medicine therapy can improve serum fibrosis markers， noninvasive liver fibrosis scores， and liver stiffness measurement in PBC patients with liver fibrosis， with a relatively good safety profile and a potential to delay or even reverse the progression of PBC-related liver fibrosis. However， current evidence is mainly derived from small-scale or short-term clinical observational studies， and in the future， large-scale high-quality randomized controlled trials and long-term follow-up studies are needed in combination with modern scientific technologies to explore underlying mechanisms， thereby further validating its efficacy and promoting the establishment of an evidence-based precise diagnosis and treatment system based on integrated traditional Chinese and Western medicine therapies. Through in-depth research， TCM is expected to play a more important role in the treatment of PBC-related liver fibrosis.
- Primary Biliary Cholangitis /
- Hepatic Fibrosis /
- Anti-Hepato Fibrosis Agents （TCD） /
- Therapeutics

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参考文献(37)

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