胰岛素样生长因子-‍Ⅰ（IGF-‍Ⅰ‍‍）在肝硬化预后评估和治疗中的作用

汪彦平; 郑亚; 张惠芳; 王慧敏; 马小彤; 陈兆峰

doi:10.12449/JCH250628

胰岛素样生长因子-‍Ⅰ（IGF-‍Ⅰ‍‍）在肝硬化预后评估和治疗中的作用

DOI: 10.12449/JCH250628

汪彦平^{1, 2a},
郑亚^{2a, 2b},
张惠芳^{1, 2a},
王慧敏^{1, 2a},
马小彤^{1, 2a},
陈兆峰^{2a, 2b, 2c, , ,}

1.
兰州大学第一临床医学院，兰州 730000
2a.
兰州大学第一医院消化科，兰州 730000
2b.
兰州大学第一医院甘肃省消化系疾病临床医学研究中心，兰州 730000
2c.
兰州大学第一医院消化内镜中心，兰州 730000

基金项目:

甘肃省科技重大专项计划 (23JRRA1487)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：汪彦平负责选题，文献检索与筛选，初稿撰写；张惠芳、王慧敏、马小彤参与文献检索与筛选；郑亚、陈兆峰负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
陈兆峰， zhfchen@lzu.edu.cn （ORCID： 0000-0001-5623-6432）

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- 被引次数: 0
出版历程
- 收稿日期: 2024-10-08
- 录用日期: 2024-11-13
- 出版日期: 2025-06-25

Role of insulin-like growth factor-‍Ⅰ in prognostic evaluation and treatment of liver cirrhosis

Yanping WANG^{1, 2a},
Ya ZHENG^{2a, 2b},
Huifang ZHANG^{1, 2a},
Huimin WANG^{1, 2a},
Xiaotong MA^{1, 2a},
Zhaofeng CHEN^{2a, 2b, 2c
, ,
,}

1.
The First Clinical Medical College of Lanzhou University，Lanzhou 730000，China
2a.
Department of Gastroenterology，The First Hospital of Lanzhou University，Lanzhou 730000，China
2b.
Gansu Province Clinical Research Center for Digestive Diseases，The First Hospital of Lanzhou University，Lanzhou 730000，China
2c.
Gastrointestinal Endoscopy Center，The First Hospital of Lanzhou University，Lanzhou 730000，China

Research funding:

Gansu Province Science and Technology Major Project Plan (23JRRA1487)

More Information

Corresponding author: CHEN Zhaofeng， zhfchen@lzu.edu.cn （ORCID： 0000-0001-5623-6432）

摘要

摘要: 胰岛素样生长因子-‍Ⅰ（IGF-‍Ⅰ）作为胰岛素样生长因子家族的关键成员，主要在肝脏合成并广泛分布于人体，参与细胞增殖、分化、代谢及凋亡等生理过程。研究表明，IGF-‍Ⅰ水平与肝硬化严重程度呈负相关，主要通过抑制肝纤维化、促进DNA损伤修复、调控脂质代谢等多种途径影响肝硬化疾病进程。监测IGF-‍Ⅰ水平有望为改善肝硬化患者预后提供评估指标；刺激IGF-‍Ⅰ的作用途径或调节其表达水平有望成为肝硬化的治疗新方法。本文综述了IGF-‍Ⅰ在肝硬化中的研究进展，以期为肝硬化的诊治提供新思路。
- 肝硬化 /
- 肝纤维化 /
- 胰岛素样生长因子Ⅰ /
- 预后
Abstract: As a key member of the insulin-like growth factor family， insulin-like growth factor-‍Ⅰ （IGF-‍Ⅰ） is mainly synthesized in the liver and is widely distributed in the human body， and it is involved in the physiological processes such as cell proliferation， differentiation， metabolism， and apoptosis. Studies have shown that the level of IGF-‍Ⅰ is negatively correlated with the severity of liver cirrhosis， and IGF-‍Ⅰ mainly affects the progression of liver cirrhosis by inhibiting liver fibrosis， promoting DNA damage repair， and regulating lipid metabolism. Monitoring of IGF-‍Ⅰ level is expected to provide an evaluation indicator for improving the prognosis of patients with liver cirrhosis， and stimulating the action pathway of IGF-‍Ⅰ or regulating its expression level may become a new method for the treatment of liver cirrhosis. This article reviews the research advances in IGF-‍Ⅰ in liver cirrhosis， in order to provide new ideas for the diagnosis and treatment of liver cirrhosis.
- Liver Cirrhosis /
- Hepatic Fibrosis /
- Insulin-Like Growth Factor Ⅰ /
- Prognosis

HTML全文

注： HSC，肝星状细胞。

图 1 IGF-‍Ⅰ/IGF-‍Ⅰ‍‍R在肝纤维化中的作用机制

Figure 1. The mechanism of IGF-Ⅰ/IGF-Ⅰ‍R in liver fibrosis

下载: 全尺寸图片幻灯片

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