血红素加氧酶在代谢相关脂肪性肝病中的作用及调控机制

费景兰; 李道政; 武俊超; 王雷

doi:10.12449/JCH250522

血红素加氧酶在代谢相关脂肪性肝病中的作用及调控机制

DOI: 10.12449/JCH250522

费景兰¹,
李道政¹,
武俊超²,
王雷^3, , ,

1.
河南中医药大学第一附属医院脾胃肝胆科，郑州 450000
2.
河南中医药大学护理学院，郑州 450046
3.
山东中医药高等专科学校，山东烟台 264100

基金项目:

河南省重点研发与推广专项项目 (232102310450);

河南省中医药科学研究专项课题 (2022JDZX089);

河南省医学科技公关计划项目 (RKX202201009);

河南省社会科学规划委托项目 (2024XWT005)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：费景兰负责课题设计，资料分析，撰写论文；李道政参与收集及分析文献资料；武俊超参与修改论文；王雷负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
王雷， hyzhaohushan@163.com （ORCID： 0009-0002-8488-5741）

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- 被引次数: 0
出版历程
- 收稿日期: 2024-09-07
- 录用日期: 2024-11-08
- 出版日期: 2025-05-25

Role and regulatory mechanism of heme oxygenase in metabolic associated fatty liver disease

1.
Spleen，Stomach and Hepatobiliary Department，The First Affiliated Hospital of Henan University of Chinese Medicine，Zhengzhou 450000，China
2.
School of Nursing，Henan University of Chinese Medicine，Zhengzhou 450046，China
3.
Shandong College of Traditional Chinese Medicine，Yantai，Shandong 264100，China

Research funding:

Special Project of Key R & D and Promotion in Henan Province (232102310450);

Henan Province Chinese Medicine Scientific Research Special Project (2022JDZX089);

Henan Provincial Medical Science and Technology Public Relations Programme (RKX202201009);

Henan Provincial Social Sciences Planning Project (2024XWT005)

More Information

Corresponding author: WANG Lei， hyzhaohushan@163.com （ORCID： 0009-0002-8488-5741）

摘要

摘要: 本文系统梳理血红素加氧酶（HO）在代谢相关脂肪性肝病（MAFLD）发病机制中的作用与关系，重点探讨了HO的生物学功能、在肝脏中的表达调控、与脂质代谢的关系，以及在炎症反应与氧化应激中的调节作用，旨在揭示HO在MAFLD中的潜在治疗靶点和机制，为未来的治疗策略提供新的视角和方向。
- 代谢相关脂肪性肝病 /
- 血红素加氧酶 /
- 治疗学
Abstract: This article systematically reviews the role and relationship of heme oxygenase （HO） in the pathogenesis of metabolic associated fatty liver disease （MAFLD） and discusses the biological function of HO， its expression in the liver， its association with lipid metabolism， and its regulatory role in inflammatory reaction and oxidative stress， in order to reveal the potential therapeutic targets and mechanism of HO in MAFLD and provide new perspectives and directions for future treatment strategies.
- Metabolic Associated Fatty Liver Disease /
- Heme Oxygenase /
- Therapeutics

HTML全文

图 1 HO在MAFLD中的调控机制

Figure 1. Control mechanism of HO in MAFLD

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参考文献(51)

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