基于女性偏倚现象探讨性激素调控T淋巴细胞介导自身免疫性肝炎的作用机制

王海强; 孙大沙; 王晗; 田家华; 崔馨月; 李明

doi:10.12449/JCH250421

基于女性偏倚现象探讨性激素调控T淋巴细胞介导自身免疫性肝炎的作用机制

DOI: 10.12449/JCH250421

王海强¹,
孙大沙²,
王晗²,
田家华²,
崔馨月²,
李明^1, , ,

1.
黑龙江中医药大学附属第一医院消化二科，哈尔滨 150040
2.
黑龙江中医药大学第一临床医学院，哈尔滨 150040

基金项目:

国家中医药管理局第五批全国中医临床优秀人才研修项目（国中医药人教函〔2022〕1号） ;

黑龙江省中医药科研基金项目 (ZHY2023-125)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：王海强、孙大沙负责文章的构思与设计，论文撰写；王晗、田家华负责论文修订；崔馨月负责论文修订与审校；李明负责最终版本修订。

详细信息

通信作者:
李明， harbinxin@163.com （ORCID： 0009-0000-7315-464X）

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出版历程
- 收稿日期: 2024-07-24
- 录用日期: 2024-09-04
- 出版日期: 2025-04-25

Mechanism of action of sex hormones in regulating T cell-mediated autoimmune hepatitis： A study based on the phenomenon of female bias

1.
Second Department of Gastroenterology，The First Affiliated Hospital of Heilongjiang University of Chinese Medicine，Harbin 150040，China
2.
The First Clinical College of Heilongjiang University of Chinese Medicine，Harbin 150040，China

Research funding:

The Fifth Batch of National TCM Clinical Excellent Talents Training Project of the State Administration of Traditional Chinese Medicine （The Teaching Letter of Chinese Medicine ［2022］ No.1） ;

Heilongjiang Province Traditional Chinese Medicine Research Fund Project (ZHY2023-125)

More Information

Corresponding author: LI Ming， harbinxin@163.com （ORCID： 0009-0000-7315-464X）

摘要

摘要: 自身免疫性肝炎（AIH）是一种以肝实质破坏和慢性纤维化为特征的自身免疫性疾病，常由T淋巴细胞介导发生。AIH的发病机制涉及多个因素，包括性别、地域、环境因素以及遗传易感性等。在AIH中，常出现女性偏倚现象，即女性发病风险远高于男性，这种性别差异与多种因素相关，性激素可能是导致AIH女性偏向性的重要因素之一，然而机制尚不完全清楚。深入了解性激素在AIH发病中的作用机制将有助于更好理解该病的发病机理，并可能为未来的治疗方法及预防策略的开发提供重要线索。本文综述雌激素和雄激素通过调控T淋巴细胞调节AIH发病的作用机制，以期为深入探讨性激素在AIH病因学中的潜在作用提供新思路和新方向。
- 肝炎，自身免疫性 /
- 偏倚 /
- 性腺甾类激素 /
- T淋巴细胞
Abstract: Autoimmune hepatitis （AIH） is an autoimmune disease characterized by liver parenchymal destruction and chronic fibrosis， and it is often mediated by T cells. The pathogenesis of AIH involves multiple factors， including sex， region， environmental factors， and genetic susceptibility. A notable predisposition is observed in female individuals， and the incidence rate of AIH in female individuals is significantly higher than that in male individuals. This sex difference is associated with various factors， and sex hormones may be an important cause of the female predominance of AIH， although the specific mechanisms remain unclear. An in-depth understanding of the mechanism of action of sex hormones in the pathogenesis of AIH will help to better understand the pathogenesis of the disease and may provide important clues for developing future treatment methods and prevention strategies. This article reviews the mechanism of action of estrogen and androgen in regulating the pathogenesis of AIH by regulating T cells， in order to provide new ideas and directions for further exploring the potential role of sex hormones in the etiology of autoimmune diseases.
- Hepatitis， Autoimmune /
- Bias /
- Gonadal Steroid Hormones /
- T-Lymphocytes

HTML全文

注： AR，雄激素受体；ERα，雌激素受体α；ERβ，雌激素受体β；NO，一氧化氮；COX2，环氧合酶-2；PPAR-α，过氧化物酶体增殖物激活受体-α；Foxp3，叉状头/翅膀状螺旋转录因子3；AHR，芳香烃受体；AHRR，AHR抑制因子；ARNT，AHR核易位子；SFGL2，纤维蛋白原样蛋白2；Th，辅助性T淋巴细胞；Treg，调节性T淋巴细胞。

图 1 性激素调控T淋巴细胞在AIH中的作用机制

Figure 1. The mechanism of sex hormones regulating T lymphocytes in AIH

下载: 全尺寸图片幻灯片

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