肝衰竭肠道屏障损伤与环鸟苷酸-腺苷酸合酶（cGAS）-干扰素基因刺激因子（STING）信号通路的关系

唐巧; 周超; 张宁; 宫嫚

doi:10.12449/JCH250328

肝衰竭肠道屏障损伤与环鸟苷酸-腺苷酸合酶（cGAS）-干扰素基因刺激因子（STING）信号通路的关系

DOI: 10.12449/JCH250328

唐巧^{1, 2},
周超¹,
张宁¹,
宫嫚^1, , ,

1.
解放军总医院第五医学中心中医肝病科，北京 100039
2.
南方医科大学中医药学院，广州 510515

基金项目:

“十三五”国家科技重大专项课题 (2018ZX10725-505-001-010);

国家自然科学基金青年项目 (82305067)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：宫嫚负责课题设计，拟定写作思路，指导撰写文章并最后定稿；张宁、周超参与收集整理文献材料，修改论文；唐巧负责撰写论文。

详细信息

通信作者:
宫嫚， gongman302@ 163.com （ORCID： 0000-0003-2716-4331）

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- 被引次数: 0
出版历程
- 收稿日期: 2024-06-07
- 录用日期: 2024-07-17
- 出版日期: 2025-03-25

Association between intestinal barrier disruption in liver failure and the cGAS-STING signaling pathway

Qiao TANG^{1, 2},
Chao ZHOU¹,
Ning ZHANG¹,
Man GONG^{1
, ,
,}

1.
Department of Traditional Chinese Medicine Liver Disease，The Fifth Medical Center of Chinese PLA General Hospital，Beijing 100039，China
2.
School of Traditional Chinese Medicine，Southern Medical University，Guangzhou 510515，China

Research funding:

Major National Science and Technology Projects in the 13th Five-Year Plan (2018ZX10725-505-001-010);

Natural Science Foundation for the Youth of China (82305067)

More Information

Corresponding author: GONG Man， gongman302@ 163.com （ORCID： 0000-0003-2716-4331）

摘要

摘要: 肝衰竭是常见的严重肝病综合征，病死率高。肠道屏障作为一个整体，其功能和结构的完整性与肝衰竭发生发展密切相关。环鸟苷酸-腺苷酸合酶（cGAS）-干扰素基因刺激因子（STING）信号通路通过识别病原体入侵及宿主自身细胞损伤产生的DNA，诱导Ⅰ型干扰素的产生，参与先天免疫反应。大量研究表明，cGAS-STING通路的激活对肠道屏障的细胞结构、黏膜成分及共生菌群均能产生影响。本文概述了cGAS-STING信号通路与肝衰竭肠道屏障损伤之间的关系，希望为临床肝衰竭的治疗提供新思路。
- 肝功能衰竭 /
- 胃肠道微生物组 /
- 信号通路
Abstract: Liver failure is a common severe syndrome of liver diseases with high mortality. The function and structural integrity of the intestinal barrier as an entity are closely associated with the development and progression of liver failure. The cGAS-STING signaling pathway can participate in innate immune response by recognizing DNA produced by pathogen invasion and host cell damage and inducing the production of type I interferon. Numerous studies have shown that activation of the cGAS-STING pathway can significantly impact the cellular structure， mucosal components， and commensal bacteria of the intestinal barrier. This article reviews the interplay between the cGAS-STING signaling pathway and intestinal barrier disruption in liver failure， in order to provide novel insights for the clinical management of liver failure.
- Liver Failure /
- Gastrointestinal Microbiome /
- Signaling Pathway

HTML全文

注： IEL，上皮内淋巴细胞；DC，树突状细胞。

图 1 肠道屏障组成结构

Figure 1. Components of intestinal barrier

下载: 全尺寸图片幻灯片

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