基因工程人血清白蛋白的研发与应用

高沿航; 牛俊奇

doi:10.12449/JCH250304

基因工程人血清白蛋白的研发与应用

DOI: 10.12449/JCH250304

高沿航^{1, 2, 3},
牛俊奇^{1, 2, 3, , ,}

1.
吉林大学第一医院肝胆胰内科，传染病与病原生物学中心，长春 130021
2.
吉林省肝脏代谢重点实验室，长春 130021
3.
中国- 新加坡一带一路肝脏病学研究联合实验室，长春 130021

基金项目:

国家自然科学基金 (U24A20654);

国家自然科学基金 (82170602);

吉林省中青年科技创新卓越人才项目 (20220508079RC);

吉林省自然科学基金自由探索重点项目 (YDZJ202401427ZYTS);

吉林省肝脏代谢重点实验室 (YDZJ202502CXJD002);

国家重点研发计划 (2024YFE0213800)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：高沿航负责论文设计，拟定写作思路，撰写论文；牛俊奇指导撰写文章并最后定稿。

详细信息

通信作者:
牛俊奇， junqiniu@aliyun.com （ORCID： 0000-0002-1696-6008）

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出版历程
- 收稿日期: 2025-01-13
- 录用日期: 2025-02-01
- 出版日期: 2025-03-25

The development and application of genetically engineered human serum albumin

Yanhang GAO^{1, 2, 3},
Junqi NIU^{1, 2, 3
, ,
,}

1.
Department of Hepatology，The First Hospital of Jilin University，Center of Infectious Diseases and Pathogen Biology，Changchun 130021，China
2.
Jilin Provincial Key Laboratory of Metabolic Liver Diseases，Jilin University，Changchun 130021，China
3.
China-Singapore Belt and Road Joint Laboratory on Liver Disease Research，Changchun 130021，China

Research funding:

National Natural Science Foundation of China (U24A20654);

National Natural Science Foundation of China (82170602);

The Project for Middle-aged and Young Excellent Technological Innovation Talents of Jilin Province (20220508079RC);

Natural Science Foundation for Self-Exploration Research of Jilin Province (YDZJ202401427ZYTS);

Jilin Provincial Key Laboratory of Metabolic Liver Diseases (YDZJ202502CXJD002);

National Key Research and Development Program of China (2024YFE0213800)

More Information

Corresponding author: NIU Junqi， junqiniu@aliyun.com （ORCID： 0000-0002-1696-6008）

摘要

摘要: 人血清白蛋白（HSA）是血浆中最丰富的蛋白质，具有多种生物学功能及临床用途。易于储存、半衰期长且充足、稳定的功能性HSA分子供应，一直是未被满足的临床需求，因此，亟需开发大规模生产HSA的替代方法。基因工程技术可将HSA基因克隆到微生物、动物、植物宿主上进行高效表达，为HSA的大规模生产提供了新的可能。本文通过对重组HSA（rHSA）在不同表达系统以及利用异种动物如猪、牛等生产rHSA的研究进展进行综述，以期引发对基因工程技术在HSA生产中的应用潜力以及rHSA在未来生物医药领域重要性的关注。
- 人血清白蛋白 /
- 肝疾病 /
- 基因工程
Abstract: Human serum albumin （HSA） is the most abundant protein in plasma and has many biological functions and clinical applications. An adequate and stable supply of functional HSA molecules that are easy to store and have a long half-life is still an unmet clinical need. Therefore， it is extremely necessary to develop alternative methods for large-scale production of HSA. Genetic engineering techniques can clone the HSA gene into microorganism， animal， and plant hosts for efficient expression， which provides new possibilities for the large-scale production of HSA. This article reviews the advances in recombinant HSA （rHSA） in different expression systems and the production of rHSA by xenogeneic animals such as pigs and cattle， in order to draw attention to the application potential of genetic engineering techniques in HSA production and the importance of rHSA in the biomedical field in future.
- Human Serum Albumin /
- Liver Diseases /
- Genetic Engineering

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参考文献(15)

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