内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗

李岫滟; 雷娜; 宋虹霏; 曾玲; 王东; 穆杰

doi:10.12449/JCH241126

内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗

DOI: 10.12449/JCH241126

李岫滟¹,
雷娜²,
宋虹霏¹,
曾玲¹,
王东¹,
穆杰^1, , ,

1.
成都中医药大学基础医学院，成都 611137
2.
重庆市中医院肛肠科，重庆 400021

基金项目:

国家自然科学基金青年项目 (82104655);

四川省自然科学基金面上项目 (2024NSFSC0692)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：李岫滟负责查阅文献，撰写论文；曾玲负责归纳文献，分析资料；雷娜、宋虹霏负责拟定思路，修改论文；王东、穆杰负责指导撰写并最后定稿。

详细信息

通信作者:
穆杰， 1041415560@qq.com （ORCID： 0000-0003-3466-238X）

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- 被引次数: 0
出版历程
- 收稿日期: 2024-01-26
- 录用日期: 2024-04-08
- 出版日期: 2024-11-25

The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies

Xiuyan LI¹,
Na LEI²,
Hongfei SONG¹,
Ling ZENG¹,
Dong WANG¹,
Jie MU^{1
, ,
,}

1.
School of Basic Medical Sciences，Chengdu University of Traditional Chinese Medicine，Chengdu 611137，China
2.
Chongqing Traditional Chinese Medicine Hospital，Chongqing 400021，China

Research funding:

Youth Fund of National Natural Science Foundation of China (82104655);

General Project of National Science Foundation of Sichuan Province (2024NSFSC0692)

More Information

Corresponding author: MU Jie， 1041415560@qq.com （ORCID： 0000-0003-3466-238X）

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）是以肝脂肪变性为主要特征的一系列疾病谱的概括，是一种代谢相关性疾病，也是肝纤维化、肝硬化和肝癌的重要风险因子。内质网是调节脂代谢的核心场所，而非折叠蛋白反应是内质网应激（ERS）的重要过程。基于内质网在代谢相关疾病中的重要应激作用，本文将从ERS角度，探寻其与NAFLD之间的影响机制，对NAFLD病理发展过程中脂质代谢、炎症反应、细胞死亡、纤维化及ERS靶向治疗的相关研究进展进行综述。
- 非酒精性脂肪性肝病 /
- 内质网应激 /
- 非折叠蛋白质应答 /
- 分子靶向治疗
Abstract: Non-alcoholic fatty liver disease （NAFLD） is a series of diseases characterized by hepatic steatosis and is also a metabolism-associated disease and an important factor for liver fibrosis， liver cirrhosis， and hepatocellular carcinoma. Endoplasmic reticulum is a core organelle for the regulation of lipid metabolism， and unfolded protein response is an important process of endoplasmic reticulum stress （ERS）. Based on the important stress role of endoplasmic reticulum in metabolism-associated diseases， this article explores the influencing mechanism between ERS and NAFLD and reviews the research advances in lipid metabolism， inflammatory response， hepatocyte death， fibrosis， and ERS-targeted therapies in the pathological development of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Endoplasmic Reticulum Stress /
- Unfolded Protein Response /
- Molecular Targeted Therapy

HTML全文

图 1 UPR通路介导的NAFLD疾病进展

注： IP3R，肌醇1，4，5-三磷酸IP3受体；TRAF2，TNF受体相关因子2；ASK，凋亡信号调节激酶；GSH，谷胱甘肽过氧化物酶；ROS，活性氧；ACC，乙酰-CoA羧化酶；TLR，Toll 样受体；MDA，丙二醛；LPO，脂质过氧化；COL1A1，胶原蛋白1A1。黑色箭头（促进），红色箭头（抑制）。

Figure 1. UPR pathway-mediated disease progression in NAFLD

下载: 全尺寸图片幻灯片

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