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内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗

李岫滟 雷娜 宋虹霏 曾玲 王东 穆杰

引用本文:
Citation:

内质网应激在非酒精性脂肪性肝病中的作用及相关靶向治疗

DOI: 10.12449/JCH241126
基金项目: 

国家自然科学基金青年项目 (82104655);

四川省自然科学基金面上项目 (2024NSFSC0692)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:李岫滟负责查阅文献,撰写论文;曾玲负责归纳文献,分析资料;雷娜、宋虹霏负责拟定思路,修改论文;王东、穆杰负责指导撰写并最后定稿。
详细信息
    通信作者:

    穆杰, 1041415560@qq.com (ORCID: 0000-0003-3466-238X)

The role of endoplasmic reticulum stress in non-alcoholic fatty liver disease and related targeted therapies

Research funding: 

Youth Fund of National Natural Science Foundation of China (82104655);

General Project of National Science Foundation of Sichuan Province (2024NSFSC0692)

More Information
    Corresponding author: MU Jie, 1041415560@qq.com (ORCID: 0000-0003-3466-238X)
  • 摘要: 非酒精性脂肪性肝病(NAFLD)是以肝脂肪变性为主要特征的一系列疾病谱的概括,是一种代谢相关性疾病,也是肝纤维化、肝硬化和肝癌的重要风险因子。内质网是调节脂代谢的核心场所,而非折叠蛋白反应是内质网应激(ERS)的重要过程。基于内质网在代谢相关疾病中的重要应激作用,本文将从ERS角度,探寻其与NAFLD之间的影响机制,对NAFLD病理发展过程中脂质代谢、炎症反应、细胞死亡、纤维化及ERS靶向治疗的相关研究进展进行综述。

     

  • 图  1  UPR通路介导的NAFLD疾病进展

    注: IP3R,肌醇1,4,5-三磷酸IP3受体;TRAF2,TNF受体相关因子2;ASK,凋亡信号调节激酶;GSH,谷胱甘肽过氧化物酶;ROS,活性氧;ACC,乙酰-CoA羧化酶;TLR,Toll 样受体;MDA,丙二醛;LPO,脂质过氧化;COL1A1,胶原蛋白1A1。黑色箭头(促进),红色箭头(抑制)。

    Figure  1.  UPR pathway-mediated disease progression in NAFLD

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  • 收稿日期:  2024-01-26
  • 录用日期:  2024-04-08
  • 出版日期:  2024-11-25
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