外泌体在肝衰竭中的调控机制及其在临床诊疗中的应用价值

童话; 罗越; 王亚东

doi:10.12449/JCH240928

外泌体在肝衰竭中的调控机制及其在临床诊疗中的应用价值

DOI: 10.12449/JCH240928

河北医科大学第三医院感染科，石家庄 050051

基金项目:

河北省自然科学基金 (H2023206042);

河北省政府资助临床医学优秀人才项目 (ZF2023082)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：童话、罗越负责查阅文献，撰写文章；王亚东负责指导立题，文章修改与审校。

详细信息

通信作者:
王亚东， wangyadong@hebmu.edu.cn （ORCID： 0000-0003-0140-0674）

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- 被引次数: 0
出版历程
- 收稿日期: 2023-12-28
- 录用日期: 2024-02-08
- 出版日期: 2024-09-25

Regulatory mechanism of exosomes in liver failure and the application value in diagnosis and treatment

Department of Infectious Diseases，Third Hospital of Hebei Medical University，Shijiazhuang 050051，China

Research funding:

Natural Science Foundation of Hebei Province (H2023206042);

Government Funding for Excellent Clinical Medicine Talent Program (ZF2023082)

More Information

Corresponding author: WANG Yadong， wangyadong@hebmu.edu.cn （ORCID： 0000-0003-0140-0674）

摘要

摘要: 外泌体是介导细胞间物质与信息传递的重要媒介，源自肝细胞、肝干细胞或肝外间充质干细胞等的外泌体通过抑制免疫炎症反应、拮抗氧化应激与凋亡、诱导自噬等多种方式促进损伤肝细胞的修复与再生，发挥对肝衰竭的保护作用。本文综述外泌体在肝衰竭发病中的分子调控机制及其对肝衰竭发生发展与预后转归的影响，旨在评价其作为肝衰竭诊断标志物与治疗靶点的潜在价值。
- 肝功能衰竭 /
- 外泌体 /
- 间充质干细胞 /
- 肝细胞
Abstract: Exosomes are an important vehicle for mediating material transportation and information transmission between cells， and the exosomes derived from hepatocytes， liver stem cells or extrahepatic mesenchymal stem cells promote the recovery and regeneration of damaged hepatocytes by inhibiting immune inflammatory response， antagonizing against oxidative stress and apoptosis， and inducing autophagy， thereby exerting a protective effect against liver failure. This article reviews the molecular mechanism of exosomes in regulating the pathogenesis of liver failure and its effect on the development， progression， and prognosis of liver failure， in order to assess the potential value of exosomes as a diagnostic marker and a therapeutic target.
- Liver Failure /
- Exosomes /
- Mesenchymal Stem Cells /
- Hepatocytes

HTML全文

图 1 外泌体的来源及其用于肝衰竭诊断与治疗的潜在价值

Figure 1. Origin of exosomes and the potential value to diagnosis and treatment of liver failure

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