炎症细胞因子在肝硬化患者糖代谢紊乱中的作用

吴云冲; 杨颜颜; 李川; 吴小欢; 林世德

doi:10.12449/JCH240926

炎症细胞因子在肝硬化患者糖代谢紊乱中的作用

DOI: 10.12449/JCH240926

遵义医科大学附属医院感染科，贵州遵义 563000

基金项目:

国家自然科学基金 (81860114)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：吴云冲负责对研究思路的设计、论文的撰写；吴云冲、杨颜颜、李川、吴小欢负责查阅相关文献；林世德负责指导修改论文及最后定稿。

详细信息

通信作者:
林世德， linshide6@zmc.edu.cn （ORCID： 0000-0001-8803-4069）

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- 被引次数: 0
出版历程
- 收稿日期: 2023-12-13
- 录用日期: 2024-02-22
- 出版日期: 2024-09-25

Role of inflammatory cytokines in disorder of glucose metabolism in patients with liver cirrhosis

Department of Infectious Diseases，Affiliated Hospital of Zunyi Medical University，Zunyi，Guizhou 563000，China

Research funding:

National Natural Science Foundation of China (81860114)

More Information

Corresponding author: LIN Shide， linshide6@zmc.edu.cn （ORCID： 0000-0001-8803-4069）

摘要

摘要: 近年来对肝硬化发生、发展过程中白细胞介素-1β、白细胞介素-6、白细胞介素-10、白细胞介素-17、肿瘤坏死因子-α、干扰素-γ、C反应蛋白等常见的炎症细胞因子的作用及机制有了更深入的了解，对炎症细胞因子与糖代谢紊乱及胰岛功能受损的相关性研究也取得了较大的进展。本文综述了肝硬化患者炎症细胞因子及其在糖代谢紊乱、胰岛功能受损中的作用，为阐明肝源性糖尿病的发生机制及其临床管理提供理论依据。
- 肝硬化 /
- 胰岛素抵抗 /
- 炎症 /
- 细胞因子类
Abstract: In recent years， there has been a deeper understanding of the role and mechanisms of common inflammatory cytokines in the development and progression of liver cirrhosis， such as interleukin-1β， interleukin-6， interleukin-10， interleukin-17， tumor necrosis factor-α， interferon-γ， and C-reactive protein， and significant achievements have also been made in the research on the association of these inflammatory cytokines with disorder of glucose metabolism and pancreatic islet dysfunction. This article reviews the role of inflammatory cytokines in patients with liver cirrhosis and their impact on disorder of glucose metabolism and pancreatic islet dysfunction， in order to provide a theoretical basis for clarifying the pathogenesis of hepatogenous diabetes and performing the clinical management of the disease.
- Liver Cirrhosis /
- Insulin Resistance /
- Inflammation /
- Cytokines

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参考文献(60)

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