炎症细胞因子在肝硬化患者糖代谢紊乱中的作用
DOI: 10.12449/JCH240926
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作者贡献声明:吴云冲负责对研究思路的设计、论文的撰写;吴云冲、杨颜颜、李川、吴小欢负责查阅相关文献;林世德负责指导修改论文及最后定稿。
Role of inflammatory cytokines in disorder of glucose metabolism in patients with liver cirrhosis
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摘要: 近年来对肝硬化发生、发展过程中白细胞介素-1β、白细胞介素-6、白细胞介素-10、白细胞介素-17、肿瘤坏死因子-α、干扰素-γ、C反应蛋白等常见的炎症细胞因子的作用及机制有了更深入的了解,对炎症细胞因子与糖代谢紊乱及胰岛功能受损的相关性研究也取得了较大的进展。本文综述了肝硬化患者炎症细胞因子及其在糖代谢紊乱、胰岛功能受损中的作用,为阐明肝源性糖尿病的发生机制及其临床管理提供理论依据。Abstract: In recent years, there has been a deeper understanding of the role and mechanisms of common inflammatory cytokines in the development and progression of liver cirrhosis, such as interleukin-1β, interleukin-6, interleukin-10, interleukin-17, tumor necrosis factor-α, interferon-γ, and C-reactive protein, and significant achievements have also been made in the research on the association of these inflammatory cytokines with disorder of glucose metabolism and pancreatic islet dysfunction. This article reviews the role of inflammatory cytokines in patients with liver cirrhosis and their impact on disorder of glucose metabolism and pancreatic islet dysfunction, in order to provide a theoretical basis for clarifying the pathogenesis of hepatogenous diabetes and performing the clinical management of the disease.
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Key words:
- Liver Cirrhosis /
- Insulin Resistance /
- Inflammation /
- Cytokines
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