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中药复方逆转肝纤维化及早期肝硬化的作用机制

张鹏 郑世豪 苟思媛 谢金池 杨先照 叶永安

引用本文:
Citation:

中药复方逆转肝纤维化及早期肝硬化的作用机制

DOI: 10.12449/JCH240924
基金项目: 

国家自然科学基金青年科学基金 (82104810)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:张鹏负责课题设计,资料分析,撰写论文;郑世豪、苟思媛、谢金池、杨先照参与检索文献、修改论文;张鹏、叶永安拟定写作思路并最后定稿。
详细信息
    通信作者:

    张鹏, zp891223@126.com (ORCID: 0000-0003-0215-3572)

    叶永安, yonganye2022@163.com (ORCID: 0000-0001-9765-4665)

The mechanism of compound traditional Chinese medicine prescriptions in reversal of liver fibrosis and early liver cirrhosis

Research funding: 

Youth Science Foundation of National Natural Science Foundation of China (82104810)

More Information
  • 摘要: 肝纤维化、肝硬化是多种慢性肝病进展后的共同结局。研究表明,肝纤维化及一定程度的肝硬化是可以逆转的。中药复方逆转肝纤维化、早期肝硬化疗效确切,但作用机制尚未完全明确。本文通过梳理国内外相关文献,总结了中药复方起效涉及的6个主要机制表型(即抑制肝脏炎症与调控免疫,调控肝星状细胞活化及细胞外基质生成,促进细胞外基质降解,逆转肝窦毛细血管化,调控肝脏细胞再生以及调节肠道菌群),并分析了各个表型领域研究的进展与不足。未来中药复方研究可围绕上述表型进行实验探索和验证,对有确切作用的表型上下游信号进一步深入探究。本文旨在帮助厘清中药复方疗效机制研究的方向和思路,为阐明中药复方科学实质提供依据。

     

  • 图  1  中药复方逆转肝纤维化及早期肝硬化机制示意图

    Figure  1.  Diagram for the mechanisms of compound traditional Chinese medicine prescriptions in reversal of liver fibrosis and early liver cirrhosis

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