局部治疗联合系统治疗在肝细胞癌转化治疗中的价值
DOI: 10.12449/JCH240903
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:朱超凡负责文献检索和分析及文章的撰写;王晓东负责文章的思路设计,文献深度分析及文章修改。
Value of local treatment combined with systemic therapy in conversion therapy for hepatocellular carcinoma
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摘要: 肝细胞癌是临床中最常见的恶性肿瘤之一。由于早期缺乏典型的临床表现,我国大多数患者确诊时已达中晚期,错失手术切除机会,预后较差。因此通过相关治疗手段将不可切除肝细胞癌转化为可切除肝细胞癌的探索十分必要。近年来,随着经动脉介入治疗、放射治疗技术等局部治疗的不断进步完善、新的靶向及免疫药物的临床应用,为肝细胞癌的转化治疗模式带来了新的机遇和挑战,而局部治疗联合系统治疗产生更好联合治疗作用,提高手术转化率。本文旨在对目前局部联合系统治疗在肝细胞癌转化治疗中的价值,为不可切除肝细胞癌的临床治疗提供参考。Abstract: Hepatocellular carcinoma (HCC) is one of the most common malignant tumors in clinical practice. Due to the lack of typical clinical manifestations in the early stage, most patients in China are in the advanced stage at the time of confirmed diagnosis and thus lose the opportunity for surgical resection, which leads to a poor prognosis. Therefore, it is necessary to explore related therapies for converting unresectable HCC into resectable HCC. In recent years, the improvement in local therapy such as transarterial interventional therapies and radiation therapy technology, together with the clinical application of new targeted therapies and immune checkpoint inhibitors, has brought new opportunities and challenges in the conversion therapy for advanced HCC, and local therapy combined with systemic therapy may have a good synergistic effect, improve the conversion rate of surgery. This article investigates the value of local therapy combined with systemic therapy in the conversion therapy for HCC, in order to provide a basis for the clinical treatment of unresectable HCC.
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