中药活性成分调控糖代谢抗胆管癌的分子机制
DOI: 10.12449/JCH240832
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:赵方言负责资料分析,论文撰写;尹怡检索文献,收集数据;李姗、王祥麒负责拟定写作思路,修改论文及最后定稿。
Molecular mechanism of traditional Chinese medicine active components in regulating glucose metabolism against cholangiocarcinoma
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摘要: 胆管癌是一种高度异质性的肿瘤,其发病隐匿、病情凶险、恶性程度高、预后极差。葡萄糖是胆管癌增殖和转移的主要能量来源,胆管癌细胞在快速增殖过程中其糖代谢途径会被重新编辑,产生大量能量以满足自身需求。中医药在胆管癌治疗中具有独特优势,中药活性成分已被证明可以通过调控糖代谢抑制胆管癌的发生和发展。本文对胆管癌中的糖代谢特点和中药活性成分调控糖代谢抗胆管癌进行综述,为胆管癌的治疗提供新思路。
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关键词:
- 胆管肿瘤 /
- 碳水化合物代谢 /
- 中药 /
- 药理作用分子作用机制(中药)
Abstract: Cholangiocarcinoma is a highly heterogeneous tumor with an insidious onset, severe conditions, a high degree of malignancy, and an extremely poor prognosis. Glucose is a major energy source for the proliferation and metastasis of cholangiocarcinoma, and the glucose metabolism pathway of cholangiocarcinoma cells will be re-edited in the process of rapid proliferation to produce a large amount of energy for their own needs. Traditional Chinese medicine has unique advantages in the treatment of cholangiocarcinoma, and studies have shown that the active components of traditional Chinese medicine can inhibit the development and progression of cholangiocarcinoma by regulating glucose metabolism. This article reviews the characteristics of glucose metabolism in cholangiocarcinoma and the role of the active components of traditional Chinese medicine in regulating glucose metabolism against cholangiocarcinoma, in order to provide new ideas for the treatment of cholangiocarcinoma. -
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