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胆道微生物群在常见胆道疾病发生发展中的作用

霍丽 畅智慧

引用本文:
Citation:

胆道微生物群在常见胆道疾病发生发展中的作用

DOI: 10.12449/JCH240831
基金项目: 

国家自然科学基金 (82272097)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:霍丽负责收集整理文献,撰写论文;畅智慧负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    畅智慧, cmuwisdom@126.com (ORCID: 0000-0002-7697-6435)

Role of biliary microbiota in the development and progression of common biliary tract diseases

Research funding: 

National Natural Science Foundation of China (82272097)

More Information
    Corresponding author: CHANG Zhihui, cmuwisdom@126.com (ORCID: 0000-0002-7697-6435)
  • 摘要: 胆道微生物群的组成与胆道疾病的发生和发展密切相关。胆道微生物群的失衡可能导致胆结石、胆道感染、自身免疫性胆管炎和胆管癌等一系列胆道疾病的发生。本文整理了胆道微生物群与胆道疾病关系的相关文献并进行综述,总结胆道微生物群对各种胆道疾病的影响,以及胆道中特定菌群在胆道疾病中发挥的作用,以期指导进一步的临床研究,为胆道疾病的预防、诊断、治疗提供新见解。

     

  • 图  1  胆道细菌在胆结石形成机制中的作用

    Figure  1.  The role of biliary bacteria in the mechanism of gallstone formation

    图  2  胆道细菌在CCA发病中的作用

    Figure  2.  The role of biliary tract bacteria in the pathogenesis of CCA

  • [1] SWANSON KS, de VOS WM, MARTENS EC, et al. Effect of fructans, prebiotics and fibres on the human gut microbiome assessed by 16S rRNA-based approaches: A review[J]. Benef Microbes, 2020, 11( 2): 101- 129. DOI: 10.3920/BM2019.0082.
    [2] LI ZQ, CHU JT, SU FX, et al. Characteristics of bile microbiota in cholelithiasis, perihilar cholangiocarcinoma, distal cholangiocarcinoma, and pancreatic cancer[J]. Am J Transl Res, 2022, 14( 5): 2962- 2971.
    [3] SINAGRA E, UTZERI E, MORREALE GC, et al. Microbiota-gut-brain axis and its affect inflammatory bowel disease: Pathophysiological concepts and insights for clinicians[J]. World J Clin Cases, 2020, 8( 6): 1013- 1025. DOI: 10.12998/wjcc.v8.i6.1013.
    [4] NASCIMENTO FSD, SUZUKI MO, TABA JV, et al. Analysis of biliary MICRObiota in hepatoBILIOpancreatic diseases compared to healthy people[MICROBILIO]: Study protocol[J]. PLoS One, 2020, 15( 11): e0242553. DOI: 10.1371/journal.pone.0242553.
    [5] BOYER JL. Bile formation and secretion[J]. Compr Physiol, 2013, 3( 3): 1035- 1078. DOI: 10.1002/cphy.c120027.
    [6] CSENDES A, BURDILES P, MALUENDA F, et al. Simultaneous bacteriologic assessment of bile from gallbladder and common bile duct in control subjects and patients with gallstones and common duct stones[J]. Arch Surg, 1996, 131( 4): 389- 394. DOI: 10.1001/archsurg.1996.01430160047008.
    [7] JIMÉNEZ E, SÁNCHEZ B, FARINA A, et al. Characterization of the bile and gall bladder microbiota of healthy pigs[J]. Microbiologyopen, 2014, 3( 6): 937- 949. DOI: 10.1002/mbo3.218.
    [8] MOLINERO N, RUIZ L, MILANI C, et al. The human gallbladder microbiome is related to the physiological state and the biliary metabolic profile[J]. Microbiome, 2019, 7( 1): 100. DOI: 10.1186/s40168-019-0712-8.
    [9] BERG G, RYBAKOVA D, FISCHER D, et al. Correction to: Microbiome definition re-visited: Old concepts and new challenges[J]. Microbiome, 2020, 8( 1): 119. DOI: 10.1186/s40168-020-00905-x.
    [10] WU T, ZHANG ZG, LIU B, et al. Gut microbiota dysbiosis and bacterial community assembly associated with cholesterol gallstones in large-scale study[J]. BMC Genomics, 2013, 14: 669. DOI: 10.1186/1471-2164-14-669.
    [11] YE FQ, SHEN HZ, LI Z, et al. Influence of the biliary system on biliary bacteria revealed by bacterial communities of the human biliary and upper digestive tracts[J]. PLoS One, 2016, 11( 3): e0150519. DOI: 10.1371/journal.pone.0150519.
    [12] SCHNEIDER J, DE WAHA P, HAPFELMEIER A, et al. Risk factors for increased antimicrobial resistance: A retrospective analysis of 309 acute cholangitis episodes[J]. J Antimicrob Chemother, 2014, 69( 2): 519- 525. DOI: 10.1093/jac/dkt373.
    [13] SUNG JY, COSTERTON JW, SHAFFER EA. Defense system in the biliary tract against bacterial infection[J]. Dig Dis Sci, 1992, 37( 5): 689- 696. DOI: 10.1007/BF01296423.
    [14] LEE J, PARK JS, BAE J, et al. Bile microbiome in patients with recurrent common bile duct stones and correlation with the duodenal microbiome[J]. Life(Basel), 2022, 12( 10): 1540. DOI: 10.3390/life12101540.
    [15] KIM MH, MYUNG SJ, SEO DW, et al. Association of periampullary diverticula with primary choledocholithiasis but not with secondary choledocholithiasis[J]. Endoscopy, 1998, 30( 7): 601- 604. DOI: 10.1055/s-2007-1001363.
    [16] LAI KH, PENG NJ, LO GH, et al. Prediction of recurrent choledocholithiasis by quantitative cholescintigraphy in patients after endoscopic sphincterotomy[J]. Gut, 1997, 41( 3): 399- 403. DOI: 10.1136/gut.41.3.399.
    [17] CHEN M, WANG L, WANG Y, et al. Risk factor analysis of post-ERCP cholangitis: A single-center experience[J]. Hepatobiliary Pancreat Dis Int, 2018, 17( 1): 55- 58. DOI: 10.1016/j.hbpd.2018.01.002.
    [18] MAKI T. Pathogenesis of calcium bilirubinate gallstone: Role of E. coli, beta-glucuronidase and coagulation by inorganic ions, polyelectrolytes and agitation[J]. Ann Surg, 1966, 164( 1): 90- 100. DOI: 10.1097/00000658-196607000-00010.
    [19] TAJEDDIN E, SHERAFAT SJ, MAJIDI MRS, et al. Association of diverse bacterial communities in human bile samples with biliary tract disorders: A survey using culture and polymerase chain reaction-denaturing gradient gel electrophoresis methods[J]. Eur J Clin Microbiol Infect Dis, 2016, 35( 8): 1331- 1339. DOI: 10.1007/s10096-016-2669-x.
    [20] HUANG D, WAN XJ. Research progress in the formation mechanism of bile duct stones[J]. Adv Clin Med, 2023, 9( 10): 16950- 16959.

    黄丹, 宛新建. 胆管结石形成机制的研究进展[J]. 临床医学进展, 2023, 9( 10): 16950- 16959.
    [21] HU FL, CHEN HT, GUO FF, et al. Biliary microbiota and mucin 4 impact the calcification of cholesterol gallstones[J]. Hepatobiliary Pancreat Dis Int, 2021, 20( 1): 61- 66. DOI: 10.1016/j.hbpd.2020.12.002.
    [22] NOMURA T, SHIRAI Y, HATAKEYAMA K. Enterococcal bactibilia in patients with malignant biliary obstruction[J]. Dig Dis Sci, 2000, 45( 11): 2183- 2186. DOI: 10.1023/a:1026640603312.
    [23] KIM B, PARK JS, BAE J, et al. Bile microbiota in patients with pigment common bile duct stones[J]. J Korean Med Sci, 2021, 36( 15): e94. DOI: 10.3346/jkms.2021.36.e94.
    [24] CHOE JW, LEE JM, HYUN JJ, et al. Analysis on microbial profiles& components of bile in patients with recurrent CBD stones after endoscopic CBD stone removal: A preliminary study[J]. J Clin Med, 2021, 10( 15): 3303. DOI: 10.3390/jcm10153303.
    [25] GUZIOR DV, QUINN RA. Review: Microbial transformations of human bile acids[J]. Microbiome, 2021, 9( 1): 140. DOI: 10.1186/s40168-021-01101-1.
    [26] BELZER C, KUSTERS JG, KUIPERS EJ, et al. Urease induced calcium precipitation by Helicobacter species may initiate gallstone formation[J]. Gut, 2006, 55( 11): 1678- 1679. DOI: 10.1136/gut.2006.098319.
    [27] SIPOS P, KRISZTINA H, BLÁZOVICS A, et al. Cholecystitis, gallstones and free radical reactions in human gallbladder[J]. Med Sci Monit, 2001, 7( 1): 84- 88.
    [28] GRIGOR'EVA IN, ROMANOVA TI. Gallstone disease and microbiome[J]. Microorganisms, 2020, 8( 6): 835. DOI: 10.3390/microorganisms8060835.
    [29] HAN JY, WU SD, FAN Y, et al. Biliary microbiota in choledocholithiasis and correlation with duodenal microbiota[J]. Front Cell Infect Microbiol, 2021, 11: 625589. DOI: 10.3389/fcimb.2021.625589.
    [30] LIU J, LIU B, LI HF, et al. Etiological analysis of biliary tract infection[J]. Chin J Nosocomiology, 2018, 28( 20): 3111- 3114. DOI: 10.11816/cn.ni.2018-182836.

    刘娟, 刘波, 李惠芬, 等. 胆道感染病原学分析[J]. 中华医院感染学杂志, 2018, 28( 20): 3111- 3114. DOI: 10.11816/cn.ni.2018-182836.
    [31] HU FL, SHANG D, ZHANG HX, et al. A review of Tokyo Guidelines 2018 for the management of acute biliary infections[J]. Chin J Pract Surg, 2018, 38( 7): 763- 766. DOI: 10.19538/j.cjps.issn1005-2208.2018.07.15.

    胡凤林, 尚东, 张浩翔, 等.《东京指南(2018)》急性胆道感染诊疗策略更新解读[J]. 中国实用外科杂志, 2018, 38( 7): 763- 766. DOI: 10.19538/j.cjps.issn1005-2208.2018.07.15.
    [32] XIONG GZ, ZHANG JF, DAI XP, et al. Bacterial spectrum and antimicrobial resistance of pathogens from bile culture in patients with biliary tract infection[J]. Chin J Nosocomiology, 2012, 22( 1): 198- 199.

    熊国祚, 张俊方, 戴先鹏, 等. 胆道感染患者胆汁培养的菌谱调查及耐药性分析[J]. 中华医院感染学杂志, 2012, 22( 1): 198- 199.
    [33] DALE AP, WOODFORD N. Extra-intestinal pathogenic Escherichia coli(ExPEC): Disease, carriage and clones[J]. J Infect, 2015, 71( 6): 615- 626. DOI: 10.1016/j.jinf.2015.09.009.
    [34] WU ZY, WU XS, YAO WY, et al. Pathogens' distribution and changes of antimicrobial resistance in the bile of acute biliary tract infection patients[J]. Chin J Surg, 2021, 59( 1): 24- 31. DOI: 10.3760/cma.j.cn112139-20200717-00559.

    吴自友, 吴向嵩, 姚文衍, 等. 急性胆道感染患者胆汁病原菌分布及耐药率变迁[J]. 中华外科杂志, 2021, 59( 1): 24- 31. DOI: 10.3760/cma.j.cn112139-20200717-00559.
    [35] China Antimicrobial Resistance Surveillance System. Antimicrobial resistance of bacteria from bile: surveillance report from China Antimicrobial Resistance Surveillance System in 2014-2019[J]. Chin J Infect Contr, 2021, 20( 1): 76- 84. DOI: 10.12138/j.issn.1671-9638.20216177.

    全国细菌耐药监测网. 全国细菌耐药监测网2014—2019年胆汁细菌耐药监测报告[J]. 中国感染控制杂志, 2021, 20( 1): 76- 84. DOI: 10.12138/j.issn.1671-9638.20216177.
    [36] MUSSA M, PÉREZ-CRESPO PMM, LOPEZ-CORTES LE, et al. Risk factors and predictive score for bacteremic biliary tract infections due to Enterococcus faecalis and Enterococcus faecium: A multicenter cohort study from the PROBAC project[J]. Microbiol Spectr, 2022, 10( 4): e0005122. DOI: 10.1128/spectrum.00051-22.
    [37] ZHAO CW, LIU SS, BAI X, et al. A retrospective study on bile culture and antibiotic susceptibility patterns of patients with biliary tract infections[J]. Evid Based Complement Alternat Med, 2022, 2022: 9255444. DOI: 10.1155/2022/9255444.
    [38] SARCOGNATO S, SACCHI D, GRILLO F, et al. Autoimmune biliary diseases: Primary biliary cholangitis and primary sclerosing cholangitis[J]. Pathologica, 2021, 113( 3): 170- 184. DOI: 10.32074/1591-951X-245.
    [39] KUMMEN M, THINGHOLM LB, RÜHLEMANN MC, et al. Altered gut microbial metabolism of essential nutrients in primary sclerosing cholangitis[J]. Gastroenterology, 2021, 160( 5): 1784- 1798. DOI: 10.1053/j.gastro.2020.12.058.
    [40] OLSSON R, BJÖRNSSON E, BÄCKMAN L, et al. Bile duct bacterial isolates in primary sclerosing cholangitis: A study of explanted livers[J]. J Hepatol, 1998, 28( 3): 426- 432. DOI: 10.1016/s0168-8278(98)80316-4.
    [41] LIWINSKI T, ZENOUZI R, JOHN C, et al. Alterations of the bile microbiome in primary sclerosing cholangitis[J]. Gut, 2020, 69( 4): 665- 672. DOI: 10.1136/gutjnl-2019-318416.
    [42] HIRAMATSU K, HARADA K, TSUNEYAMA K, et al. Amplification and sequence analysis of partial bacterial 16S ribosomal RNA gene in gallbladder bile from patients with primary biliary cirrhosis[J]. J Hepatol, 2000, 33( 1): 9- 18. DOI: 10.1016/s0168-8278(00)80153-1.
    [43] CARDINALE V. Classifications and misclassification in cholangiocarcinoma[J]. Liver Int, 2019, 39( 2): 260- 262. DOI: 10.1111/liv.13998.
    [44] KHAN SA, THOMAS HC, DAVIDSON BR, et al. Cholangiocarcinoma[J]. Lancet, 2005, 366( 9493): 1303- 1314. DOI: 10.1016/s0140-6736(05)67530-7.
    [45] BRINDLEY PJ, BACHINI M, ILYAS SI, et al. Cholangiocarcinoma[J]. Nat Rev Dis Primers, 2021, 7: 65. DOI: 10.1038/s41572-021-00300-2.
    [46] PINTO C, GIORDANO DM, MARONI L, et al. Role of inflammation and proinflammatory cytokines in cholangiocyte pathophysiology[J]. Biochim Biophys Acta Mol Basis Dis, 2018, 1864( 4 Pt B): 1270- 1278. DOI: 10.1016/j.bbadis.2017.07.024.
    [47] KHAN SA, TAVOLARI S, BRANDI G. Cholangiocarcinoma: Epidemiology and risk factors[J]. Liver Int, 2019, 39( Suppl 1): 19- 31. DOI: 10.1111/liv.14095.
    [48] BARNER-RASMUSSEN N, PUKKALA E, JUSSILA A, et al. Epidemiology, risk of malignancy and patient survival in primary sclerosing cholangitis: A population-based study in Finland[J]. Scand J Gastroenterol, 2020, 55( 1): 74- 81. DOI: 10.1080/00365521.2019.1707277.
    [49] PEREIRA P, AHO V, AROLA J, et al. Bile microbiota in primary sclerosing cholangitis: Impact on disease progression and development of biliary dysplasia[J]. PLoS One, 2017, 12( 8): e0182924. DOI: 10.1371/journal.pone.0182924.
    [50] DYSON JK, BEUERS U, JONES DEJ, et al. Primary sclerosing cholangitis[J]. Lancet, 2018, 391( 10139): 2547- 2559. DOI: 10.1016/s0140-6736(18)30300-3.
    [51] SUTTIPRAPA S, SOTILLO J, SMOUT M, et al. Opisthorchis viverrini proteome and host-parasite interactions[J]. Adv Parasitol, 2018, 102: 45- 72. DOI: 10.1016/bs.apar.2018.06.002.
    [52] XU T, ZHANG B, ZHOU WC. Research progress on the relationship between biliary flora and cholangiocarcinoma[J]. Chin J Bases Clin Gen Surg, 2021, 28( 3): 404- 408. DOI: 10.7507/1007-9424.202006047.

    徐涛, 张波, 周文策. 胆道菌群与胆管癌关系的研究进展[J]. 中国普外基础与临床杂志, 2021, 28( 3): 404- 408. DOI: 10.7507/1007-9424.202006047.
    [53] CHNG KR, CHAN SH, NG AHQ, et al. Tissue microbiome profiling identifies an enrichment of specific enteric bacteria in Opisthorchis viverrini associated cholangiocarcinoma[J]. EBioMedicine, 2016, 8: 195- 202. DOI: 10.1016/j.ebiom.2016.04.034.
    [54] CHEN BR, FU SW, LU LG, et al. A preliminary study of biliary microbiota in patients with bile duct stones or distal cholangiocarcinoma[J]. Biomed Res Int, 2019, 2019: 1092563. DOI: 10.1155/2019/1092563.
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  • 收稿日期:  2023-11-22
  • 录用日期:  2024-01-02
  • 出版日期:  2024-08-25
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