生物钟调控的线粒体动力学在非酒精性脂肪性肝病中的作用

张策; 苗嘉芮; 樊旭

doi:10.12449/JCH240826

生物钟调控的线粒体动力学在非酒精性脂肪性肝病中的作用

DOI: 10.12449/JCH240826

张策^a,
苗嘉芮^a,
樊旭^b, , ,

a.
辽宁中医药大学针灸推拿学院，沈阳 110000
b.
辽宁中医药大学中西医结合学院，沈阳 110000

基金项目:

辽宁省教育厅基本科研项目 (LJKMZ20221307)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张策负责撰写论文；苗嘉芮负责设计并讨论文章构架；樊旭负责指导撰写文章、修改论文。

详细信息

通信作者:
樊旭， fanxulw@163.com （ORCID： 0000-0001-8567-7026）

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- 文章访问数: 95
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- 被引次数: 0
出版历程
- 收稿日期: 2023-12-07
- 录用日期: 2023-12-28
- 出版日期: 2024-08-25

The role of circadian clock-controlled mitochondrial dynamics in nonalcoholic fatty liver disease

Ce ZHANG^a,
Jiarui MIAO^a,
Xu FAN^{b
, ,
,}

a.
School of Acupuncture and Massage，Liaoning University of Traditional Chinese Medicine，Shenyang 110000，China
b.
School of Integrated Traditional Chinese and Western Medicine，Liaoning University of Traditional Chinese Medicine，Shenyang 110000，China

Research funding:

Basic Research Projects of Education Department of Liaoning Province (LJKMZ20221307)

More Information

Corresponding author: FAN Xu， fanxulw@163.com （ORCID： 0000-0001-8567-7026）

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）是一种与代谢异常密切相关的疾病，是目前最常见的慢性肝病之一。线粒体是高度动态的细胞器，参与肝脏中的多种代谢和生物能量通路，通过线粒体动力学对环境变化做出高度动态反应。生物钟能够调控线粒体动力学，使其表现出节律性变化。当昼夜节律紊乱时，线粒体动力学失去节律性，使得线粒体不能对不同环境中不断变化的能量需求做出反应，导致NAFLD的发生发展。本文总结了生物钟调控的线粒体动力学在NAFLD病因学中的重要作用。
- 非酒精性脂肪性肝病 /
- 生物钟 /
- 线粒体动力学
Abstract: Nonalcoholic fatty liver disease （NAFLD） is a disease closely associated with metabolic abnormalities and is currently one of the most common chronic liver diseases. Mitochondria are highly dynamic organelles involved in a variety of metabolic and bioenergetic pathways in the liver， and they respond to environmental changes in a highly dynamic manner through mitochondrial dynamics. The circadian clock is able to modulate mitochondrial dynamics， making it exhibit rhythmic changes. In case of circadian rhythm disorders， mitochondrial dynamics loses rhythmicity， and mitochondria are unable to respond to changing energy demands in different environments， leading to the development and progression of NAFLD. This article summarizes the important role of circadian clock-controlled mitochondrial dynamics in the etiology of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Biological Clocks /
- Mitochondrial Dynamics

HTML全文

图 1 生物钟调控线粒体动力学的相关机制示意图

Figure 1. Schematic diagram of the relevant mechanisms by which circadian clock controls mitochondrial dynamics

下载: 全尺寸图片幻灯片

图 2 生物钟调控的线粒体动力学在NAFLD中的作用机制示意图

Figure 2. Schematic diagram of the role of clock-controlled mitochondrial dynamics in NAFLD

下载: 全尺寸图片幻灯片

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