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《2024年亚太肝病学会临床实践指南： 慢加急性肝衰竭患者急性肾损伤的管理》摘译
DOI: 10.12449/JCH240811
利益冲突声明：本文不存在任何利益冲突。
作者贡献声明：胡家轩负责文章翻译；韩涛负责文章审校。
An excerpt of Asian Pacific Association for the Study of the Liver clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure in 2024
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摘要: 慢加急性肝衰竭是一种以器官衰竭快速进展为特征的综合征，短期病死率高。肾脏是其最容易受累的肝外器官之一。近期发布的《2024年亚太肝病学会临床实践指南：慢加急性肝衰竭患者急性肾损伤的管理》对慢加急性肝衰竭患者急性肾损伤的早期诊断、病理生理学、预防和管理提出相关共识声明和推荐意见，同时也指出未来需要开展更多高质量的研究。Abstract: Acute-on-chronic liver failure （ACLF） is a syndrome characterized by the rapid progression of organ failure and has a high short-term mortality rate. Kidney is one of the most frequently affected extrahepatic organs in ACLF patients. Recently Asian Pacific Association for the Study of the Liver （APASL） published APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure， which proposed related consensus statements and recommendations for the early diagnosis， pathophysiology， prevention， and management of acute kidney injury in patients with ACLF， and it also highlighted the need for more high-quality studies in the future.
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Key words:
- Acute-On-Chronic Liver Failure /
- Acute Kidney Injury /
- Practice Guideline
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表 1 证据和推荐等级
Table 1. Level of evidence and recommendation
项目 说明 证据等级 1级 RCT的Meta分析或高质量RCT 2级 较低质量的RCT或前瞻性对照研究 3级 病例对照研究或回顾性研究 4级 无比较或对照组的病例系列 5级 病例报道或者专家意见 推荐 强 一致性>80% 弱 一致性<80% 注：RCT，随机对照试验。
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[1] MAIWALL R, SINGH SP, ANGELI P, et al. APASL clinical practice guidelines on the management of acute kidney injury in acute-on-chronic liver failure[J]. Hepatol Int, 2024, 18( 3): 833- 869. DOI: 10.1007/s12072-024-10650-0. -
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