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铁死亡抑制蛋白1在肝脏疾病中的作用机制及潜在治疗靶点

王思思 王亚茹 刘睿 秦洁

引用本文:
Citation:

铁死亡抑制蛋白1在肝脏疾病中的作用机制及潜在治疗靶点

DOI: 10.12449/JCH240731
基金项目: 

山西省自然科学研究面上项目 (202203021211059)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:王思思负责设计论文框架,起草论文;王亚茹、刘睿负责论文修改;秦洁负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    秦洁, hopejieqin@sohu.com (ORCID: 0000-0002-7249-093X)

Mechanism of action and potential therapeutic targets of ferroptosis suppressor protein 1 in liver diseases

Research funding: 

Natural Science Research General Project of Shanxi Province (202203021211059)

More Information
  • 摘要: 铁死亡抑制蛋白1(FSP1)是最近发现除谷胱甘肽过氧化酶4之外的另一个主要的铁死亡调节因子,能够清除细胞内的活性氧和脂质自由基,抑制铁死亡的发生。鉴于肝脏在铁和脂质代谢中的关键作用及其对氧化损伤的易感性,越来越多的证据表明FSP1在代谢相关脂肪性肝病、肝细胞癌、急性肝衰竭、酒精性肝损伤等肝脏疾病中发挥重要作用,FSP1相关靶点有望成为一种潜在的治疗选择。本文旨在对FSP1进行全面综述,重点总结FSP1在几种常见肝病的病理生理学中的作用,强调其作为肝脏疾病靶点的潜力,为肝脏疾病的治疗提供新思路。

     

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  • 收稿日期:  2023-12-02
  • 录用日期:  2024-01-29
  • 出版日期:  2024-07-25
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