IRE1α/TRAF2/JNK信号通路在急性肝衰竭发展中的作用机制及潜在价值

关海梅; 张衎; 陈玮钰; 李国宝; 曾阳玲; 张日云; 王恬雯; 谢宝华; 毛德文

doi:10.12449/JCH240633

IRE1α/TRAF2/JNK信号通路在急性肝衰竭发展中的作用机制及潜在价值

DOI: 10.12449/JCH240633

1.
广西中医药大学研究生院，南宁 530001
2.
广西中医药大学第一附属医院肝病科，南宁 530023

基金项目:

国家自然科学基金 (82274434);

国家自然科学基金 (81960841);

国家自然科学基金 (82060848);

广西中医药大学研究生教育创新计划 (YCBZ2023157)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：关海梅负责拟定写作思路并撰写文章；陈玮钰、曾阳玲负责设计论文框架；李国宝、张日云负责收集、整理相关文献；王恬雯、谢宝华负责修订论文；毛德文、张衎提供指导意见并最后定稿。

详细信息

通信作者:
毛德文， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）

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出版历程
- 收稿日期: 2023-11-15
- 录用日期: 2024-01-18
- 出版日期: 2024-06-25

Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure

1.
Graduate School，Guangxi University of Chinese Medicine，Nanning 530001，China
2.
Department of Hepatology，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

National Natural Science Foundation of China (82274434);

National Natural Science Foundation of China (81960841);

National Natural Science Foundation of China (82060848);

Guangxi University of Traditional Chinese Medicine Graduate Education Innovation Program (YCBZ2023157)

More Information

Corresponding author: MAO Dewen， mdwboshi2005@163.com （ORCID： 0000-0001-9438-9325）

摘要

摘要: 急性肝衰竭（ALF）是临床上最危重的一种肝脏疾病，严重影响我国人民生命健康。由于ALF的发病率和死亡率高、发病机制不明确、治疗手段有限，成为肝病领域亟待解决的重大难题。近年来，越来越多研究表明，内质网应激是ALF进展中一个关键的生物学过程，IRE1α/TRAF2/JNK通路作为内质网应激信号传导的一部分，在疾病的发展中发挥着放大炎症反应、促进肝细胞凋亡、抑制肝再生能力等作用。而中医药作为我国传统瑰宝，从中药单体中寻找有效防治ALF的药物成为研究热点。本文旨在通过阐述IRE1α/TRAF2/JNK通路在ALF发展中的作用机制，以及总结红景天苷、楮实子、补骨脂+五味子、黄芩素、京尼平、山柰酚、白藜芦醇、沙棘多糖提取物、木犀草素等中药单体调控该通路的潜在价值，以期为ALF的进一步研究和临床实践提供参考依据。
- 肝功能衰竭，急性 /
- 信号传导 /
- 内质网应激
Abstract: Acute liver failure （ALF） is one of the most critical liver diseases in clinical practice and seriously affects the life and health of Chinese people. Due to its high morbidity and mortality rates， unclear pathogenesis， and limited treatment methods， ALF has become a major problem that needs to be solved urgently in the field of liver diseases. In recent years， more and more studies have shown that endoplasmic reticulum stress is a key biological process in the progression of ALF， and the IRE1α/TRAF2/JNK pathway， as a part of endoplasmic reticulum stress signaling， plays a role in amplifying inflammatory response， promoting hepatocyte apoptosis， and inhibiting liver regeneration ability during the progression of diseases. As a traditional treasure of China， traditional Chinese medicine has become a research hotspot in search for effective prevention and treatment drugs for ALF from monomers of Chinese herbs. This article elaborates on the mechanism of action of the IRE1α/TRAF2/JNK pathway in the progression of ALF and summarizes the potential value of several monomers of Chinese herbs in regulating this pathway， such as salidroside， Fructus Broussonetiae， Fructus Psoraleae+Schisandra chinensis， baicalein， genipin， kaempferol， resveratrol， sea buckthorn polysaccharide extract， and luteol， in order to provide a reference for further research and clinical practice of ALF.
- Liver Failure， Acute /
- Signal Transduction /
- Endoplasmic Reticulum Stress

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