药物诱导的自身免疫样肝炎的研究进展

李勤荣; 尧颖; 徐智媛

doi:10.12449/JCH240628

药物诱导的自身免疫样肝炎的研究进展

DOI: 10.12449/JCH240628

李勤荣¹,
尧颖²,
徐智媛^1, , ,

1.
昆明医科大学第二附属医院消化内科，昆明 650000
2.
昆明医科大学附属延安医院消化内科，昆明 650051

基金项目:

国家自然科学基金 (82160106)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：李勤荣负责课题设计，资料分析，撰写论文；尧颖负责指导撰写文章；徐智媛负责指导撰写文章并最后定稿。

详细信息

通信作者:
徐智媛， xuzhiyuan0109@163.com （ORCID： 0000-0003-0289-5947）

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出版历程
- 收稿日期: 2023-10-14
- 录用日期: 2023-10-30
- 出版日期: 2024-06-25

Research advances in drug-induced autoimmune-like hepatitis

Qinrong LI¹,
Ying YAO²,
Zhiyuan XU^{1
, ,
,}

1.
Department of Gastroenterology，The Second Affiliated Hospital of Kunming Medical University，Kunming 650000，China
2.
Department of Gastroenterology，Yan’an Hospital Affiliated to Kunming Medical University，Kunming 650051，China

Research funding:

National Natural Science Foundation of China (82160106)

More Information

Corresponding author: XU Zhiyuan， xuzhiyuan0109@163.com （ORCID： 0000-0003-0289-5947）

摘要

摘要: 药物诱导的自身免疫样肝炎（DI-ALH）是药物性肝损伤的一种特殊临床表型，与自身免疫性肝炎有相似的临床特征和实验室检查，多数时候通过肝组织活检也无法直接区分，因此正确鉴别DI-ALH与自身免疫性肝炎是临床实践中的重难点。本文总结了DI-ALH的发病机制、临床特点、诊治、预后的研究进展，为临床医生提供此类疾病的诊治思路。
- 化学性与药物性肝损伤 /
- 肝炎，自身免疫性 /
- 诊断 /
- 治疗学
Abstract: Drug-induced autoimmune-like hepatitis （DI-ALH） is a special clinical phenotype of drug-induced liver injury and has similar clinical features and laboratory test results to autoimmune hepatitis， and it is often difficult to distinguish them through liver biopsy. Therefore， correct differential diagnosis DI-ALH and autoimmune hepatitis is a crucial and difficult point in clinical practice. This article analyzes the research advances in the pathogenesis， clinical features， diagnosis and treatment， and prognosis of DI-ALH， in order to provide ideas for the diagnosis and treatment of such diseases among clinicians.
- Chemical and Drug Induced Liver Injury /
- Hepatitis， Autoimmune /
- Diagnosis /
- Therapeutics

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参考文献(35)

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