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引用本文:
Citation:

重症急性胰腺炎中西医结合诊疗指南

DOI: 10.12449/JCH240608
基金项目: 

天津市中医药重点领域科技项目 (2022005);

天津市自然科学基金重点项目 (21JCZDJC00550);

天津市卫生健康委员会中医中西医结合课题重点项目 (2021006);

天津市131创新型人才团队项目 (201938)

利益冲突声明:本指南由中华中医药学会立项,参与项目制定的所有成员均签署了“利益冲突声明书”,本诊疗指南制定过程中无利益冲突,为此不会成为本诊疗指南制定的偏倚来源,无需进一步处理,已在正式工作开始前公开了利益声明和评价结果,即所有参与本诊疗指南制定的成员均和药品生产企业没有任何经济利益往来。

Guidelines for integrated traditional Chinese and Western medicine diagnosis and treatment of severe acute pancreatitis

Research funding: 

Tianjin Science and Technology Project in Key Areas of Traditional Chinese Medicine (2022005);

Tianjin Natural Science Foundation Key Project (21JCZDJC00550);

Tianjin Municipal Health Commission Key Project of Combined Traditional Chinese and Western Medicine Subjects (2021006);

Tianjin 131 Innovative Talent Team Project (201938)

  • 摘要: 重症急性胰腺炎起病急、进展快,临床病理变化复杂,病死率高达20%~30%。长期的临床实践与基础研究发现,单纯依赖西医治疗重症急性胰腺炎并不尽如人意,中西医结合治疗能够展现出更为确切的疗效,具有显著的优势。本指南以循证医学证据为基础,结合国内外指南及临床实践,广泛征求专家建议与意见,最终凝练了28个临床问题。具体阐释了重症急性胰腺炎的病因病机与诊断标准,以及中西医结合分型、病程分期、治疗与治疗的关键点,以期对重症急性胰腺炎的中西医结合诊断标准和治疗原则进行规范。该指南经中华中医药学会发布,标准编号:T/CACM 1518—2023。

     

  • 表  1  AP分类诊断系统

    Table  1.   Diagnostic system for classification of acute pancreatitis

    分级系统 轻症 中度重症 重症 危重症
    RAC分级1) 无器官功能障碍和局部并发症 出现一过性(≤48 h)器官功能障碍和/或局部并发症 出现持续性(>48 h)器官功能障碍
    DBC分级2) 无器官功能障碍和胰腺(胰周)坏死 出现一过性(≤48 h)器官功能障碍和/或无菌性坏死 出现持续性(>48 h)器官功能障碍或感染性坏死 出现持续性(>48 h)器官功能障碍和感染性坏死
    注:1)RAC分级,即修订版Atlanta分级,依据改良Marshall评分进行器官功能障碍诊断;2)DBC分级,即决定因素的分级,依据序贯器官衰竭评分系统进行器官功能障碍诊断。
    下载: 导出CSV

    表  2  改良CT严重指数评分1)标准

    Table  2.   Scoring criteria for the modified CT severity index

    特征 评分(分)
    胰腺炎性反应
    正常胰腺 0
    胰腺和/或胰周炎性改变 2
    单发或多个积液区或胰周脂肪坏死 4
    胰腺坏死
    无胰腺坏死 0
    坏死范围≤30% 2
    坏死范围>30% 4
    胰外并发症2) 2
    注:1)改良CT严重指数评分为炎性反应、坏死与胰外并发症评分之和;2)胰外并发症包括胸腔积液、腹腔积液、血管或胃肠道受累等。
    下载: 导出CSV

    表  3  BISAP评分

    Table  3.   BISAP scores

    符合以下每项标准评1分 评分(分)
    血尿素氨>8.9 mmol/L 1
    精神异常 1
    存在SIRS 1
    年龄>60岁 1
    影像检查提示胸腔积液 1
    下载: 导出CSV

    表  4  SAP中医辨证分期的论治

    Table  4.   Treatment of severe acute pancreatitis with Chinese medicine identification and staging

    病程分期 病理改变 临床表现 中医辨证 治则 代表方剂
    第一期 无菌性胰腺胰周坏死、无菌性炎性阶段 急性坏死物积聚、ACS、SIRS、MODS、急性胃肠功能损伤 正盛邪实、少阳阳明合证、阳明腑实证、结胸里实证 通里攻下、活血化瘀 大承气汤、清胰陷胸汤
    第二期 感染性胰腺胰周坏死、感染性炎症阶段 脓毒症、代偿性抗炎反应综合征、重症监护后综合征、MODS、包裹性坏死、感染性胰腺坏死 热结腑实、毒热炽盛 清热解毒、活血化瘀、通里攻下 清胰汤、清胰承气汤
    第三期 残余感染性胰腺胰周坏死、局部并发症、内分泌功能损伤、外分泌功能损伤 营养不良、局部并发症 正虚邪去、正虚邪恋、正虚邪陷 补气养血、健脾和胃 辨证方剂
    下载: 导出CSV
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  • 收稿日期:  2024-04-08
  • 录用日期:  2024-04-23
  • 出版日期:  2024-06-25
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