β-葡萄糖醛酸酶（GUS）在原发性肝内胆管结石形成中的作用

李果; 叶海军; 徐至开; 李文涛; 徐承雷; 李江

doi:10.12449/JCH240530

β-葡萄糖醛酸酶（GUS）在原发性肝内胆管结石形成中的作用

DOI: 10.12449/JCH240530

昆明医科大学第一附属医院肝胆外科，昆明 650032

基金项目:

云南省科技厅-高校联合基金项目 (202101AY070001-129)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：李果、叶海军、李江负责课题设计，资料分析，撰写论文；徐至开、李文涛、徐承雷、李江参与收集数据，修改论文；李江负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
李江， 13888836057@163.com （ORCID： 0000-0002-6872-9434）

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出版历程
- 收稿日期: 2023-08-23
- 录用日期: 2023-10-07
- 出版日期: 2024-05-25

Role of β-glucuronidase in the formation of primary intrahepatic stones

Department of Hepatobiliary Surgery，The First Affiliated Hospital of Kunming Medical University，Kunming 650032，China

Research funding:

Yunnan Province Department of Science and Technology-University Joint Fund Project (202101AY070001-129)

More Information

Corresponding author: LI Jiang， 13888836057@163.com （ORCID： 0000-0002-6872-9434）

摘要

摘要: 原发性肝内胆管结石（PIS）是我国西南地区高发和难治性疾病，对患者的生活造成极大的影响。胆道系统慢性感染产生的β-葡萄糖醛酸酶等代谢产物，在色素性结石的形成中起着重要作用，除细菌产生的外源性β-葡萄糖醛酸酶，肝内胆管细胞产生的内源性β-葡萄糖醛酸酶在结石的形成中亦扮演重要角色。本文就PIS发病机制中β-葡萄糖醛酸酶的作用研究进展予以分析，以期为PIS的防治提供可能的方式。
- 胆石 /
- 葡萄糖醛酸酶 /
- 病理过程
Abstract: Primary intrahepatic stones （PIS） is a refractory disease with a high incidence rate in Southwest China， which greatly affects the life of patients. Metabolites， such as β-glucuronidase produced by chronic biliary tract infection， play an important role in the formation of pigmented stones. In addition to exogenous β-glucuronidase produced by bacteria， endogenous β-glucuronidase produced by intrahepatic bile duct cells also plays an important role in the formation of stones. This article analyzes the research advances in the role of β-glucuronidase in the pathogenesis of PIS， in order to provide a possible method for the prevention and treatment of PIS.
- Gallstones /
- Glucuronidase /
- Pathologic Processes

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图 1 GUS可能诱导结石形成的机制

Figure 1. The mechanism by which GUS may induce stone formation

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