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β-葡萄糖醛酸酶(GUS)在原发性肝内胆管结石形成中的作用

李果 叶海军 徐至开 李文涛 徐承雷 李江

引用本文:
Citation:

β-葡萄糖醛酸酶(GUS)在原发性肝内胆管结石形成中的作用

DOI: 10.12449/JCH240530
基金项目: 

云南省科技厅-高校联合基金项目 (202101AY070001-129)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:李果、叶海军、李江负责课题设计,资料分析,撰写论文;徐至开、李文涛、徐承雷、李江参与收集数据,修改论文;李江负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    李江, 13888836057@163.com (ORCID: 0000-0002-6872-9434)

Role of β-glucuronidase in the formation of primary intrahepatic stones

Research funding: 

Yunnan Province Department of Science and Technology-University Joint Fund Project (202101AY070001-129)

More Information
  • 摘要: 原发性肝内胆管结石(PIS)是我国西南地区高发和难治性疾病,对患者的生活造成极大的影响。胆道系统慢性感染产生的β-葡萄糖醛酸酶等代谢产物,在色素性结石的形成中起着重要作用,除细菌产生的外源性β-葡萄糖醛酸酶,肝内胆管细胞产生的内源性β-葡萄糖醛酸酶在结石的形成中亦扮演重要角色。本文就PIS发病机制中β-葡萄糖醛酸酶的作用研究进展予以分析,以期为PIS的防治提供可能的方式。

     

  • 图  1  GUS可能诱导结石形成的机制

    Figure  1.  The mechanism by which GUS may induce stone formation

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  • 收稿日期:  2023-08-23
  • 录用日期:  2023-10-07
  • 出版日期:  2024-05-25
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