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Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用

林玉培 刘晓萍 罗银冰 李飞燕 廖莹莹 莫世聪 毛德文 蓝艳梅

引用本文:
Citation:

Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用

DOI: 10.12449/JCH240529
基金项目: 

国家自然科学基金 (81960841);

国家自然科学基金 (82274434);

广西自然科学基金 (2020GXNSFBA297115);

广西自然科学基金 (2023GXNSFAA026176);

广西自然科学基金创新研究团队项目 (2020GXNSFAA297070);

广西高校中青年教师科研基础能力提升项目 (2022KY0299);

广西中医药大学校级一般硕士研究生创新项目 (YCSY2022024)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:毛德文负责研究选题并拟定写作思路;廖莹莹、刘晓萍负责设计论文框架;莫世聪、罗银冰、李飞燕负责收集、整理文献材料;林玉培负责文章撰写;蓝艳梅负责审校。
详细信息
    通信作者:

    蓝艳梅, lanyanmeixueshu@163.com (ORCID: 0000-0001-9304-0594)

The relationship between the Wnt signaling pathway and liver regeneration and its role in liver diseases

Research funding: 

Natioanal Natural Science Foundation Project (81960841);

Natioanal Natural Science Foundation Project (82274434);

Guangxi Natural Science Foundation Project (2020GXNSFBA297115);

Guangxi Natural Science Foundation Project (2023GXNSFAA026176);

Guangxi Natual Science Foundation Innovation Research Team Project (2020GXNSFAA297070);

Guangxi University Young and Middle School Teachers’ Basic Research Ability Enhancement Project (2022KY0299);

Innovation Project of General Post graduates in Guangxi University of Traditional Chinese Medicine (YCSY2022024)

More Information
  • 摘要: Wnt信号通路在维持肝脏内稳态和肝脏再生过程中扮演重要角色,在成熟的健康肝脏中,Wnt信号通路大多是不活跃的,但在细胞更新或再生过程中,以及在某些病理条件、疾病、癌前状态和癌症中,Wnt信号通路被持续过度激活。持续的肝细胞损伤常常会导致慢性肝病,如肝纤维化、肝硬化及肝癌等。本文概述了Wnt信号通路的基本结构特点,详细分析了其在多种肝脏疾病病理进展所扮演的重要角色,希望为临床防治肝脏疾病提供新思路。

     

  • 图  1  Wnt信号传导通路

    Figure  1.  Wnt signaling pathway

    表  1  针对Wnt/β-catenin信号传导的药物临床试验

    Table  1.   Clinical trials of agents targeting Wnt/β-catenin signalling

    药物 类型 靶点 作用 阶段 临床试验记录
    LGK974(WNT974) 融合蛋白 Wnt配体 FZD8融合蛋白与FZD8竞争结合Wnt配体 Ⅰ期 NCT01608867,NCT02050178, NCT02069145,NCT02092363
    OMP-131R10 单抗 R-spondin 3 抑制 RSPO-LGR-ZNRF3/RNF43复合体 Ⅰ期 NCT02482441
    OTSA101 单抗 FZD10 抗FZD10型单抗 Ⅰ期 NCT01469975
    OMP-18R5 单抗 FZD受体 抗FZD受体型单抗 Ⅰ期 NCT01345201,NCT01957007, NCT01973309,NCT02005315
    DKN-01 单抗 DKK1 抗DKK1型单抗,抑制非典型β-catenin传导途径 Ⅰ期, Ⅱ期 NCT01457417,NCT01711671, NCT02013154,NCT02375880
    BHQ880 单抗 DKK1 抗DKK1型单抗,抑制非典型β-catenin传导途径 Ⅰ期, Ⅱ期 NCT00741377,NCT01302886, NCT01337752
    Foxy-5 小肽 FZD受体 Wnt 5a类似物 Ⅰ期 NCT02020291,NCT02655952
    PRI 724 小分子 β-catenin, CREB结合蛋白 下调β-catenin反应基因 Ⅰ期, Ⅱ期 NCT01302405,NCT01606579, NCT01764477,NCT02195440
    SM08502 小分子 未知 抑制β-catenin传导途径 Ⅰ期 NCT03355066
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