Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用

林玉培; 刘晓萍; 罗银冰; 李飞燕; 廖莹莹; 莫世聪; 毛德文; 蓝艳梅

doi:10.12449/JCH240529

Wnt信号通路与肝再生的关系及其在肝脏疾病中的作用

DOI: 10.12449/JCH240529

1.
广西中医药大学研究生院，南宁 530001
2a..
广西中医药大学第一附属医院中医临床研究重点实验室南宁 530023
2b..
广西中医药大学第一附属医院广西中医药防治医学分子生物重点实验室，南宁 530023

基金项目:

国家自然科学基金 (81960841);

国家自然科学基金 (82274434);

广西自然科学基金 (2020GXNSFBA297115);

广西自然科学基金 (2023GXNSFAA026176);

广西自然科学基金创新研究团队项目 (2020GXNSFAA297070);

广西高校中青年教师科研基础能力提升项目 (2022KY0299);

广西中医药大学校级一般硕士研究生创新项目 (YCSY2022024)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：毛德文负责研究选题并拟定写作思路；廖莹莹、刘晓萍负责设计论文框架；莫世聪、罗银冰、李飞燕负责收集、整理文献材料；林玉培负责文章撰写；蓝艳梅负责审校。

详细信息

通信作者:
蓝艳梅， lanyanmeixueshu@163.com （ORCID： 0000-0001-9304-0594）

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出版历程
- 收稿日期: 2023-08-28
- 录用日期: 2023-10-12
- 出版日期: 2024-05-25

The relationship between the Wnt signaling pathway and liver regeneration and its role in liver diseases

1.
Graduate School of Guangxi University of Chinese Medicine，Nanning 530001，China
2a..
Key Laboratory of Traditional Chinese Medicine Clinical Research
2b..
Guangxi Key Laboratory of Molecular Biology in Traditional Chinese Medicine Prevention and Treatment，The First Affiliated Hospital of Guangxi University of Chinese Medicine，Nanning 530023，China

Research funding:

Natioanal Natural Science Foundation Project (81960841);

Natioanal Natural Science Foundation Project (82274434);

Guangxi Natural Science Foundation Project (2020GXNSFBA297115);

Guangxi Natural Science Foundation Project (2023GXNSFAA026176);

Guangxi Natual Science Foundation Innovation Research Team Project (2020GXNSFAA297070);

Guangxi University Young and Middle School Teachers’ Basic Research Ability Enhancement Project (2022KY0299);

Innovation Project of General Post graduates in Guangxi University of Traditional Chinese Medicine (YCSY2022024)

More Information

Corresponding author: LAN Yanmei， lanyanmeixueshu@163.com （ORCID： 0000-0001-9304-0594）

摘要

摘要: Wnt信号通路在维持肝脏内稳态和肝脏再生过程中扮演重要角色，在成熟的健康肝脏中，Wnt信号通路大多是不活跃的，但在细胞更新或再生过程中，以及在某些病理条件、疾病、癌前状态和癌症中，Wnt信号通路被持续过度激活。持续的肝细胞损伤常常会导致慢性肝病，如肝纤维化、肝硬化及肝癌等。本文概述了Wnt信号通路的基本结构特点，详细分析了其在多种肝脏疾病病理进展所扮演的重要角色，希望为临床防治肝脏疾病提供新思路。
- 肝疾病 /
- 肝再生 /
- Wnt信号通路 /
- β连环素
Abstract: The Wnt signaling pathway plays an important role in maintaining liver homeostasis and liver regeneration. In healthy livers， the Wnt signaling pathway is mostly inactive， but it is continuously overactivated during cell renewal or regeneration processes， as well as in certain pathological conditions， diseases， precancerous states， and cancers. Persistent liver cell injury often leads to chronic liver diseases such as liver fibrosis， liver cirrhosis， and liver cancer. This article summarizes the basic structural features of the Wnt signaling pathway and analyzes its important role in the pathological progression of various liver diseases， so as to provide new ideas for the prevention and treatment of liver diseases in clinical practice.
- Liver Diseases /
- Liver Regeneration /
- Wnt Signaling Pathway /
- beta Catenin

HTML全文

图 1 Wnt信号传导通路

Figure 1. Wnt signaling pathway

下载: 全尺寸图片幻灯片

表 1 针对Wnt/β-catenin信号传导的药物临床试验

Table 1. Clinical trials of agents targeting Wnt/β-catenin signalling

药物	类型	靶点	作用	阶段	临床试验记录
LGK974（WNT974）	融合蛋白	Wnt配体	FZD8融合蛋白与FZD8竞争结合Wnt配体	Ⅰ期	NCT01608867，NCT02050178， NCT02069145，NCT02092363
OMP-131R10	单抗	R-spondin 3	抑制 RSPO-LGR-ZNRF3/RNF43复合体	Ⅰ期	NCT02482441
OTSA101	单抗	FZD10	抗FZD10型单抗	Ⅰ期	NCT01469975
OMP-18R5	单抗	FZD受体	抗FZD受体型单抗	Ⅰ期	NCT01345201，NCT01957007， NCT01973309，NCT02005315
DKN-01	单抗	DKK1	抗DKK1型单抗，抑制非典型β-catenin传导途径	Ⅰ期， Ⅱ期	NCT01457417，NCT01711671， NCT02013154，NCT02375880
BHQ880	单抗	DKK1	抗DKK1型单抗，抑制非典型β-catenin传导途径	Ⅰ期， Ⅱ期	NCT00741377，NCT01302886， NCT01337752
Foxy-5	小肽	FZD受体	Wnt 5a类似物	Ⅰ期	NCT02020291，NCT02655952
PRI 724	小分子	β-catenin， CREB结合蛋白	下调β-catenin反应基因	Ⅰ期， Ⅱ期	NCT01302405，NCT01606579， NCT01764477，NCT02195440
SM08502	小分子	未知	抑制β-catenin传导途径	Ⅰ期	NCT03355066

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