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肝巨噬细胞调控肝癌癌前病变恶变的研究进展
DOI: 10.12449/JCH240527
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作者贡献声明：闫瑞娟负责构思文章思路，设计文章结构并撰写文章；焦俊喆、黄玉、魏海梁负责研究文献，更新、补充相关内容；闫曙光负责设计并讨论文章构架；常占杰负责基础理论指导；郭英君负责修改文章，设计文章结构并参与部分文章撰写；李京涛负责审核文章思路并修改。
Research advances in liver macrophages regulating malignant transformation of hepatic precancerous lesions
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摘要: 肝巨噬细胞是肝脏中重要的免疫细胞，其通过极化为M1型和M2型，分别表达“促炎因子”和“抑炎因子”，进而发挥调控炎症损伤反应的作用。肝祖细胞恶变是肝癌癌前病变恶性进展的核心机制，其发生的关键因素是炎症损伤微环境的持续刺激，与M1/M2巨噬细胞极化密切相关。本综述主要围绕“巨噬细胞极化-慢性炎症-肝祖细胞恶变”关系进行探讨，为肝癌癌前病变的预防和治疗提供重要的理论依据。Abstract: Liver macrophages are important immune cells in the liver， and they express proinflammatory factors and anti-inflammatory factors through polarization into M1 type and M2 type， respectively， thereby playing a role in regulating inflammatory damage response. The malignant transformation of hepatic progenitor cells is the core mechanism of the malignant progression of hepatic precancerous lesions， and its key factor is the continuous stimulation of inflammatory microenvironment， which is closely associated with M1/M2 macrophage polarization. This review mainly focuses on the association between macrophage polarization， chronic inflammation， and malignant transformation of hepatic progenitor cells， so as to provide a theoretical basis for the prevention and treatment of hepatic precancerous lesions.
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图 1 肝巨噬细胞极化平衡调控肝癌癌前病变恶变示意图
注： LPS，脂多糖；iNOS，一氧化氮合成酶；MCP-1，单核细胞趋化蛋白-1；CCL2，趋化因子配体2；PDGF，血小板衍生生长因子；Arg1，精氨酸酶1；CD206，甘露糖受体。
Figure 1. Schematic diagram of liver macrophage polarization balance regulating malignant transformation of hepatic precancerous lesion
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