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HBeAg诱导的免疫激活和免疫抑制在慢性乙型肝炎中的作用

李欣阳 涂正坤

引用本文:
Citation:

HBeAg诱导的免疫激活和免疫抑制在慢性乙型肝炎中的作用

DOI: 10.12449/JCH240525
基金项目: 

吉林省科技发展计划项目自然科学基金 (20190201245JC)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:李欣阳负责查阅文献,撰写文章;涂正坤负责拟定文章思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    涂正坤, tuzhengkun@hotmail.com (ORCID: 0000-0001-6803-2015)

Role of HBeAg-induced immune activition and immunosuppression in chronic hepatitis B

Research funding: 

Jilin Province Science and Technology Development Plan Project Natural Science Foundation Project (20190201245JC)

More Information
  • 摘要: HBV感染诱导的慢性乙型肝炎是导致肝硬化和肝癌的重要危险因素。半个世纪前,HBeAg在HBV感染者血清中首次被发现,尽管HBeAg并不参与HBV在肝细胞中的感染或复制,但其已被证实可干扰宿主先天性和适应性免疫反应,在慢性HBV感染的过程中发挥着重要的免疫激活和免疫抑制作用。HBV对于感染的肝细胞并没有细胞毒性,免疫应答介导的抗病毒作用和炎症反应决定HBV是否被清除或者诱导肝脏炎症相关疾病。因此,本文对HBeAg的形成及其在慢性HBV感染中引起的免疫激活和免疫抑制机制进行综述,重点论述HBeAg对先天免疫和适应性免疫细胞所引起的不同免疫效应,阐述了其诱导免疫反应的两面性,并探讨HBeAg在慢性HBV感染不同阶段间的转换作用。

     

  • 图  1  CHB感染各时期特征及免疫反应

    注: ERK,细胞外调节蛋白激酶;pDC,浆细胞样树突状细胞;ROS,活性氧;TLR,Toll样受体;IFN,干扰素;IL,白细胞介素;NLRP3,NOD样受体蛋白3;MDSC,骨髓源性抑制细胞;IDO,吲哚胺2,3-双加氧酶;BAFF,B淋巴细胞激活因子;TNF,肿瘤坏死因子。

    Figure  1.  Characteristics and immune responses of different stages of CHB infection

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  • 收稿日期:  2024-01-25
  • 录用日期:  2024-02-22
  • 出版日期:  2024-05-25
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