HBeAg诱导的免疫激活和免疫抑制在慢性乙型肝炎中的作用

李欣阳; 涂正坤

doi:10.12449/JCH240525

HBeAg诱导的免疫激活和免疫抑制在慢性乙型肝炎中的作用

DOI: 10.12449/JCH240525

李欣阳,
涂正坤^, ,

吉林大学第一医院肿瘤免疫实验室，长春 130021

基金项目:

吉林省科技发展计划项目自然科学基金 (20190201245JC)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：李欣阳负责查阅文献，撰写文章；涂正坤负责拟定文章思路，指导撰写文章并最后定稿。

详细信息

通信作者:
涂正坤， tuzhengkun@hotmail.com （ORCID： 0000-0001-6803-2015）

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出版历程
- 收稿日期: 2024-01-25
- 录用日期: 2024-02-22
- 出版日期: 2024-05-25

Role of HBeAg-induced immune activition and immunosuppression in chronic hepatitis B

Xinyang LI,
Zhengkun TU^{,
,}

Laboratory of Tumor Immunology，The First Hospital of Jilin University，Changchun 130021，China

Research funding:

Jilin Province Science and Technology Development Plan Project Natural Science Foundation Project (20190201245JC)

More Information

Corresponding author: TU Zhengkun， tuzhengkun@hotmail.com （ORCID： 0000-0001-6803-2015）

摘要

摘要: HBV感染诱导的慢性乙型肝炎是导致肝硬化和肝癌的重要危险因素。半个世纪前，HBeAg在HBV感染者血清中首次被发现，尽管HBeAg并不参与HBV在肝细胞中的感染或复制，但其已被证实可干扰宿主先天性和适应性免疫反应，在慢性HBV感染的过程中发挥着重要的免疫激活和免疫抑制作用。HBV对于感染的肝细胞并没有细胞毒性，免疫应答介导的抗病毒作用和炎症反应决定HBV是否被清除或者诱导肝脏炎症相关疾病。因此，本文对HBeAg的形成及其在慢性HBV感染中引起的免疫激活和免疫抑制机制进行综述，重点论述HBeAg对先天免疫和适应性免疫细胞所引起的不同免疫效应，阐述了其诱导免疫反应的两面性，并探讨HBeAg在慢性HBV感染不同阶段间的转换作用。
- 乙型肝炎，慢性 /
- 乙型肝炎e抗原 /
- 免疫激活 /
- 免疫抑制
Abstract: Chronic hepatitis B induced by HBV infection is a significant risk factor leading to liver cirrhosis and liver cancer. Half a century ago， HBeAg was first discovered in the serum of HBV infected individuals， and although HBeAg does not participate in HBV infection or replication in hepatocytes， studies have shown that it can interfere with the innate and adaptive immune responses of the host and play an important role in immune activation and immunosuppression during chronic HBV infection. HBV has no cytotoxicity to the infected hepatocytes， and the antiviral action and inflammatory response mediated by immune response determine whether HBV is cleared or induces liver inflammation-related diseases. Therefore， this article reviews the formation of HBeAg and its immune activation and immunosuppression mechanisms in chronic HBV infection， with a focus on the different immune effects caused by HBeAg on innate immune and adaptive immune cells， and this article also elaborates on the dual role of HBeAg in inducing immune responses and explores the conversion role of HBeAg in different stages of chronic HBV infection.
- Hepatitis B， Chronic /
- Hepatitis B e Antigens /
- Immune Activation /
- Immune Suppressive

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图 1 CHB感染各时期特征及免疫反应

注： ERK，细胞外调节蛋白激酶；pDC，浆细胞样树突状细胞；ROS，活性氧；TLR，Toll样受体；IFN，干扰素；IL，白细胞介素；NLRP3，NOD样受体蛋白3；MDSC，骨髓源性抑制细胞；IDO，吲哚胺2，3-双加氧酶；BAFF，B淋巴细胞激活因子；TNF，肿瘤坏死因子。

Figure 1. Characteristics and immune responses of different stages of CHB infection

下载: 全尺寸图片幻灯片

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