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一线核苷(酸)类似物经治的慢性乙型肝炎患者低病毒血症的发生及治疗策略

郑嵘炅 鲁晓擘

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一线核苷(酸)类似物经治的慢性乙型肝炎患者低病毒血症的发生及治疗策略

DOI: 10.12449/JCH240506
详细信息
    通信作者:

    鲁晓擘, xjykdluxiaobo@126.com (ORCID: 0000-0001-5532-7551)

Low-level viremia in chronic hepatitis B patients treated with first-line treatment with nucleos(t)ide analogues and its treatment strategies

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  • 摘要: 强效低耐药口服抗病毒治疗可使HBV复制受到强力抑制,但部分患者接受恩替卡韦、替诺福韦酯、丙酚替诺福韦、艾米替诺福韦治疗48周及以上仍存在低病毒血症(LLV)。国内外多项研究结果提示,抗病毒治疗后LLV与慢性乙型肝炎肝纤维化进展、失代偿期肝硬化和肝细胞癌发生风险以及长期生存率降低密切相关。因此,本文聚焦有关一线核苷(酸)类似物治疗后LLV的发生及其危险因素和临床危害以及不同的治疗方案,以期为今后慢性乙型肝炎患者LLV的治疗提供参考。

     

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  • 收稿日期:  2024-02-29
  • 录用日期:  2024-03-30
  • 出版日期:  2024-05-25
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