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儿童HBV感染: ALT水平正常患儿的抗病毒治疗

傅蕾

引用本文:
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儿童HBV感染: ALT水平正常患儿的抗病毒治疗

DOI: 10.12449/JCH240504
利益冲突声明:本文不存在任何利益冲突。
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    傅蕾, fulei92@126.com (ORCID: 0000-0001-7550-1254)

Hepatitis B virus infection in children: Antiviral therapy for children with a normal alanine aminotransferase level

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    Corresponding author: FU Lei, fulei92@126.com (ORCID: 0000-0001-7550-1254)
  • 摘要: 慢性乙型肝炎(CHB)是全球范围内的重大公共卫生问题,目前我国约有200万儿童HBV感染者。儿童感染HBV后更容易慢性化,成年后发生肝硬化以及肝癌的风险高。传统观点认为儿童HBV感染多数处于免疫耐受期,无需考虑抗病毒治疗,仅对免疫活动期和代偿期或失代偿期肝硬化的儿童CHB启动抗病毒治疗。越来越多的儿童CHB临床研究结果显示,儿童CHB抗病毒治疗(特别是以干扰素为基础的方案)应答率高,低龄儿童是临床治愈的优势人群,但对于ALT水平正常,特别是处于免疫耐受期的HBV感染的患儿是否接受抗病毒治疗仍然存在争议。本文针对儿童HBV感染的特点及ALT水平正常患儿抗病毒治疗必要性,特别是关于治疗时机等方面进行综述。

     

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  • 收稿日期:  2024-03-02
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