巨噬细胞胞葬功能在急慢性肝病中的作用机制及其靶向治疗

杨焕焕; 袁诗雨; 唐映梅

doi:10.12449/JCH240432

巨噬细胞胞葬功能在急慢性肝病中的作用机制及其靶向治疗

DOI: 10.12449/JCH240432

昆明医科大学第二附属医院消化内科，昆明 650101

基金项目:

国家自然科学基金 (82360108);

云南省医学领军人才项目 (L-2019013);

云南万人计划名医专项 (YNWR-MY-2018-028);

云南省科技人才与平台计划 (The Yunan Academician Expert Workstation 202305AF150065);

昆明医科大学第二附属医院临床研究项目 (2020ynlc010);

昆明医科大学第二附属医院临床研究项目 (ynIIT2021017)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：杨焕焕负责起草文章，对行文思路和设计有关键贡献；袁诗雨负责查阅及分析参考文献；唐映梅修改文章关键内容。

详细信息

通信作者:
唐映梅， tangyingmei_med@kmmu.edu.cn （ORCID： 0000-0002-0731-4198）

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出版历程
- 收稿日期: 2023-08-20
- 录用日期: 2023-10-07
- 出版日期: 2024-04-25

Mechanism of action of macrophage efferocytosis in acute and chronic liver diseases and related targeted therapy

Department of Gastroenterology，The Second Affiliated Hospital of Kunming Medical University，Kunming 650101，China

Research funding:

National Natural Science Foundation of China (82360108);

Medicine Leading Talents of Yunnan Province (L-2019013);

The Yunnan Wanren Project (YNWR-MY-2018-028);

Yunnan Province Science And Technology Talents and Platform Plan (The Yunan Academician Expert Workstation 202305AF150065);

Clinical Research Project of the Second Affiliated Hospital of Kunming Medical University (2020ynlc010);

Clinical Research Project of the Second Affiliated Hospital of Kunming Medical University (ynIIT2021017)

More Information

Corresponding author: TANG Yingmei， tangyingmei_med@kmmu.edu.cn （ORCID： 0000-0002-0731-4198）

摘要

摘要: 胞葬作用是指吞噬细胞（包括巨噬细胞、树突状细胞等专职吞噬细胞和上皮细胞等非专职吞噬细胞）吞噬并清除凋亡细胞的过程。肝巨噬细胞是肝脏中具有胞葬功能的主要细胞。近年来，越来越多的研究表明包括急性肝损伤、酒精性肝病、非酒精性脂肪性肝病、自身免疫性肝病、肝纤维化及肝细胞癌等在内的多种急慢性肝病均与肝巨噬细胞的胞葬作用有关。本文通过阐述巨噬细胞胞葬相关分子的表达、胞葬过程及其胞葬功能在不同肝病中作用的最新研究进展，旨在为肝病治疗提供新思路。
- 肝疾病 /
- 巨噬细胞 /
- 胞葬
Abstract: Efferocytosis refers to the process by which apoptotic cells are engulfed and cleared by phagocytes， including professional phagocytes， such as macrophages and dendritic cells， and non-professional phagocytes， such as epithelial cells. Liver macrophages are the main cells with the function of efferocytosis in the liver. In recent years， an increasing number of studies have shown that various acute and chronic liver diseases are associated with the efferocytosis function of liver macrophages， including acute liver injury， alcoholic liver disease， nonalcoholic fatty liver disease， autoimmune liver disease， liver fibrosis， and liver cancer. This article elaborates on the expression of molecules associated with the efferocytosis function of macrophages， the process of efferocytosis， and the role of efferocytosis function in different liver diseases， so as to provide new ideas for the treatment of liver diseases.
- Liver Diseases /
- Macrophages /
- Efferocytosis

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表 1 凋亡细胞和巨噬细胞胞葬相关分子

Table 1. Funeral-related molecules in apoptotic cells and macrophages

凋亡细胞胞葬配体	巨噬细胞胞葬受体	桥接分子
LPC、S1P、ATP、UTP、PS	直接受体：G2A、S1PR、P2Y2、LRP1、SRB1、BAI1、TIM-4、RAGE、TREM2 间接受体：TAM、Integrins	Gas6、ProS、MFGE8

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