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氨基酸代谢在非酒精性脂肪性肝病中的作用机制

张慧 谭明 程胜桃 陈娟

引用本文:
Citation:

氨基酸代谢在非酒精性脂肪性肝病中的作用机制

DOI: 10.12449/JCH240427
基金项目: 

国家自然科学基金面上项目 (82273423);

国家自然科学基金青年基金 (82202501)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:张慧负责查阅文献,撰写论文;谭明、程胜桃参与修改文章内容;陈娟指导文章撰写及修改,校阅论文。
详细信息
    通信作者:

    陈娟, chenjuan2014@cqmu.edu.cn (ORCID: 0000-0001-6920-7972)

Mechanism of amino acid metabolism in nonalcoholic fatty liver disease

Research funding: 

General Project of National Natural Science Foundation of China (82273423);

Youth Fund of National Natural Science Foundation of China (82202501)

More Information
  • 摘要: 非酒精性脂肪性肝病(NAFLD)是全球最普遍的慢性肝病之一,影响全球约1/4的人口,预计到2030年将成为肝移植的主要适应证。NAFLD可导致包括支链氨基酸在内的多种氨基酸水平显著异常,进而促进NAFLD的发生发展。提示除葡萄糖代谢和脂质代谢外,氨基酸代谢也在NAFLD疾病进展中发挥了重要作用。为系统了解氨基酸代谢在NAFLD中的作用及其机制,本文针对氨基酸代谢在NAFLD中的研究进展进行了综述。拟探讨氨基酸代谢在NAFLD疾病进展中发挥的作用及其相关机制,为临床防治提供思路和理论依据。

     

  • 表  1  NAFLD患者血浆氨基酸变化的代谢组学

    Table  1.   Metabolomics of plasma amino acid changes in patients with non-alcoholic fatty liver disease

    文献 年份 ALA ASN ASP CYS GLN GLU GLY HIS ILE LEU LYS PHE PRO SER TRP TYR VAL
    Yamakado等6 2017 + - + + + + + + - + + +
    Gaggini等7 2017 + + - + + + +
    Pietzner等8 2018 + + - + + + + - + + +
    Hasegawa等9 2020 + - + + + - + + + + + + - + + +
    Kaikkonen等10 2017 + - - + + + + +
    Grzych等11 2020 + +
    Goffredo等12 2017 + + + + + +
    Chashmniam等13 2019 - - + + - + +
    注:+和-分别代表NAFLD患者与健康对照者血浆氨基酸水平的显著增加或减少。ALA,丙氨酸;ASN,天冬酰胺;ASP,天冬氨酸;CYS,半胱氨酸;GLN,谷氨酰胺;GLU,谷氨酸;GLY,甘氨酸;HIS,组氨酸;ILE,异亮氨酸;LEU,亮氨酸;LYS,赖氨酸;PHE,苯丙氨酸;PRO,脯氨酸;SER,丝氨酸;TRP,色氨酸;TYR,酪氨酸;VAL,缬氨酸。
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