基于肠道微生态探讨中医药治疗非酒精性脂肪性肝病的作用机制

杨雪; 张旭; 仙晋; 谭奇纹; 于慧娟

doi:10.12449/JCH240426

基于肠道微生态探讨中医药治疗非酒精性脂肪性肝病的作用机制

DOI: 10.12449/JCH240426

杨雪¹,
张旭¹,
仙晋²,
谭奇纹²,
于慧娟^2, , ,

1.
山东中医药大学针灸推拿学院，济南 250014
2.
山东中医药大学附属医院治未病中心，济南 250014

基金项目:

山东中医药大学重点学科：中医治未病学 ;

山东中医药大学附属医院朝阳人才项目

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：杨雪、张旭负责查找文献，撰写文稿；仙晋、谭奇纹负责文章思路指导；于慧娟负责审阅文稿及最后定稿。

详细信息

通信作者:
于慧娟， huijuanyu@163.com （ORCID： 0000-0003-1180-5704）

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出版历程
- 收稿日期: 2023-09-02
- 录用日期: 2023-09-18
- 出版日期: 2024-04-25

Mechanism of action of traditional Chinese medicine in treatment of nonalcoholic fatty liver disease based on intestinal microecology

Xue YANG¹,
Xu ZHANG¹,
Jin XIAN²,
Qiwen TAN²,
Huijuan YU^{2
, ,
,}

1.
School of Acupuncture and Massage，Shandong University of Traditional Chinese Medicine，Jinan 250014，China
2.
Preventive Treatment Center，The Affiliated Hospital of Shandong University of Traditional Chinese Medicine，Jinan 250014，China

Research funding:

Key Discipline of Shandong University of Traditional Chinese Medicine： Traditional Chinese Medicine Prevention and Treatment ;

Chaoyang Talent Project of Shandong University of Traditional Chinese Medicine Affiliated Hospital

More Information

Corresponding author: YU Huijuan， huijuanyu@163.com （ORCID： 0000-0003-1180-5704）

摘要

摘要: 非酒精性脂肪性肝病（NAFLD）是一种与肥胖、胰岛素抵抗和血脂异常相关的多系统疾病，其发病机制较为复杂。肠道菌群失调与NAFLD的发病密切相关，中医药治疗可通过调节肠道菌群及其代谢产物，改善NAFLD患者的实验室指标和临床症状。本文总结了NAFLD与肠道菌群的关系、肠道菌群失调参与NAFLD的发病机制，从肠道菌群角度探讨中医药治疗改善NAFLD的可能等，以期为NAFLD的治疗拓展新的思路。
- 非酒精性脂肪性肝病 /
- 肠道菌群 /
- 中医疗法
Abstract: Nonalcoholic fatty liver disease （NAFLD） is a multisystem disease associated with obesity， insulin resistance， and dyslipidemia and has a complex pathogenesis. Studies have shown that gut microbiota dysbiosis is closely associated with the onset of NAFLD， and traditional Chinese medicine treatment can improve the laboratory markers and clinical symptoms of NAFLD patients by regulating intestinal microbiota and its metabolites. This article elaborates on the association between NAFLD and gut microbiota， the involvement of gut microbiota dysbiosis in the pathogenesis of NAFLD， and the possible mechanism of traditional Chinese medicine treatment in improving NAFLD from the perspective of gut microbiota， in order to provide new ideas for the treatment of NAFLD.
- Non-alcoholic Fatty Liver Disease /
- Gut Microbiota /
- TCM Therapy

HTML全文

表 1 疾病发展过程中肠道菌群的差异

Table 1. Differences in intestinal flora during disease development

疾病	升高		降低		参考文献
疾病	门水平	科属水平	门水平	科属水平	参考文献
单纯性脂肪肝	厚壁菌、变形杆菌、放线菌	脱硫菌	拟杆菌	阿克曼菌、瘤胃球菌科	［9］
NASH	厚壁菌门、变形杆菌	普雷沃菌属、毛螺菌科、另枝菌属、肠杆菌科	拟杆菌门（乳酸菌、瘤胃球菌）	双歧杆菌科、双歧杆菌属、拟杆菌属	［10-14］
肝硬化	变形菌门、梭菌门	肠杆菌科（属）、肠球菌科（属）、韦荣球菌属、链球菌属、梭菌属、普雷沃菌属	拟杆菌门	拟杆菌属、双歧杆菌属、瘤胃球菌属、粪球菌属	［15-19］
肝细胞癌	厚壁菌门	大肠杆菌属、肠球菌属、梭菌属、考拉杆菌属、颤螺菌属、克雷伯杆菌属、嗜血杆菌属、毛螺菌属	拟杆菌门	颤杆菌克属、粪杆菌属、粪球菌属、乳酸杆菌属、双歧杆菌属、经黏液真杆菌属	［20-24］

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参考文献(58)

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