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丙型肝炎病毒感染与器官移植

张莉 胡鹏

引用本文:
Citation:

丙型肝炎病毒感染与器官移植

DOI: 10.12449/JCH240404
利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:张莉负责设计论文框架,起草并修改论文;胡鹏负责拟定写作思路,指导撰写文章并最后定稿。
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    通信作者:

    胡鹏, hp_cq@163.com (ORCID: 0000-0001-8481-0841)

Hepatitis C virus infection and organ transplantation

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    Corresponding author: HU Peng, hp_cq@163.com (ORCID: 0000-0001-8481-0841)
  • 摘要: 近年来,在器官移植候选者和受者中预防和治疗HCV的策略发展迅速。尽管HCV感染在肝或非肝实体器官移植中不再威胁移植结果,但它们仍然是研究的焦点。由于丙型肝炎仍然是全球因肝硬化失代偿期、肝衰竭和肝细胞癌而死亡的主要原因,因此需要合适的采取器官移植,以提高生存率和生活质量。而近年来随着HCV阳性实体器官供体的增加,且对器官的需求仍显著超过供应,随着直接抗病毒药物的发展,全球逐渐开展将HCV阳性供体器官移植到HCV阴性受体中,这将可能显著提高移植率并降低等候名单死亡率。目前抗HCV治疗的有效性创造了一个重要的机会,通过增加器官移植的可及性和降低候诊死亡率将显著提高终末器官衰竭患者的生存率。

     

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  • 收稿日期:  2024-02-07
  • 录用日期:  2024-02-28
  • 出版日期:  2024-04-11
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