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肝硬化凝血障碍机制的再认识

孙荣荣 贺娜 张粉娜 张心怡 王梓依 王辉 边娜娜 闫红林

引用本文:
Citation:

肝硬化凝血障碍机制的再认识

DOI: 10.12449/JCH240330
基金项目: 

陕西省教育科学“十三五”规划课题 (SGH20Y1330)

佑安肝病传染病专科医疗联盟专项基金 (LM202003)

陕西基础科学(化学、生物学)研究院2022年度基础科学研究计划项目 (22JHQ09)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:孙荣荣负责设计论文框架,资料分析,起草论文;张心怡、王梓依、王辉、边娜娜负责文献收集;贺娜、张粉娜负责论文修改;贺娜、闫红林负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    闫红林, yanhonglin666@163.com (ORCID: 0009-0003-3060-7348)

Re-understanding of the mechanism of coagulation disorder in liver cirrhosis

Research funding: 

Shaanxi Provincial Education Science “13th Five-Year Plan” Project (SGH20Y1330);

Youan Specialist Medical Alliance for Liver and Infectious Diseases Special Fund (LM202003);

Shaanxi Institute of Basic Science (Chemistry and Biology) 2022 Basic Science Research Programme Projects (22JHQ09)

More Information
  • 摘要: 肝脏在维持机体凝血和抗凝动态平衡中发挥重要调节作用。肝硬化患者抗凝与凝血的动态平衡很脆弱,会因凝血因子减少,血小板计数下降,纤溶亢进而增加出血风险,同时还会因血管性血友病因子、凝血因子Ⅷ升高,抗凝蛋白C、抗凝蛋白S降低,凝血酶生成潜力增加,抗纤溶成分的改变而形成血栓。本文对肝硬化凝血障碍的机制进行综述,以期对临床医生关于肝硬化患者的出血或血栓性疾病的预防和治疗提供帮助。

     

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出版历程
  • 收稿日期:  2023-07-16
  • 录用日期:  2023-08-14
  • 出版日期:  2024-03-20
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