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巨噬细胞极化在肝纤维化中的调控作用机制

白小洋 张旭 海龙 丁向春

引用本文:
Citation:

巨噬细胞极化在肝纤维化中的调控作用机制

DOI: 10.12449/JCH240329
基金项目: 

宁夏自然科学基金项目 (2023AAC03584)

宁夏自然科学基金项目 (2023AAC03519)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:白小洋负责撰写与修改论文;海龙参与查阅相关文献;丁向春、张旭负责拟定写作思路,指导撰写文章并最后定稿。
详细信息
    通信作者:

    丁向春, 13619511758@163.com (ORCID: 0000-0003-0283-9419)

Regulatory effect and mechanism of macrophage polarization in liver fibrosis

Research funding: 

Ningxia Natural Science Foundation (2023AAC03584);

Ningxia Natural Science Foundation (2023AAC03519)

More Information
    Corresponding author: DING Xiangchun, 13619511758@163.com (ORCID: 0000-0003-0283-9419)
  • 摘要: 肝纤维化是一种由病毒感染、酒精、化学物质等原因导致的慢性肝损伤的愈合反应,是慢性肝脏疾病进展为肝硬化和肝癌的关键环节。肝巨噬细胞被认为是肝损伤和修复的重要介质,巨噬细胞极化趋向对肝纤维化具有双向调控作用。本文阐述不同表型的肝巨噬细胞在肝纤维化发生发展过程中的作用,以期为纤维化的防治研究提供新思路。

     

  • 图  1  巨噬细胞极化在肝纤维化中的调控作用机制

    Figure  1.  The regulatory mechanism of macrophage polarization in liver fibrosis

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出版历程
  • 收稿日期:  2023-08-10
  • 录用日期:  2023-11-10
  • 出版日期:  2024-03-20
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