巨噬细胞极化在肝纤维化中的调控作用机制

白小洋; 张旭; 海龙; 丁向春

doi:10.12449/JCH240329

巨噬细胞极化在肝纤维化中的调控作用机制

DOI: 10.12449/JCH240329

白小洋^{1a, 1b, 2},
张旭^1b,
海龙^1a,
丁向春^1a, , ,

1a.
宁夏医科大学总医院感染科，银川 750000
1b.
宁夏医科大学总医院医学科学研究院外科学研究室，银川 750000
2.
宁夏医科大学临床医学院，银川 750000

基金项目:

宁夏自然科学基金项目 (2023AAC03584);

宁夏自然科学基金项目 (2023AAC03519)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：白小洋负责撰写与修改论文；海龙参与查阅相关文献；丁向春、张旭负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
丁向春， 13619511758@163.com （ORCID： 0000-0003-0283-9419）

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- 被引次数: 0
出版历程
- 收稿日期: 2023-08-10
- 录用日期: 2023-11-10
- 出版日期: 2024-03-20

Regulatory effect and mechanism of macrophage polarization in liver fibrosis

Xiaoyang BAI^{1a, 1b, 2},
Xu ZHANG^1b,
Long HAI^1a,
Xiangchun DING^{1a
, ,
,}

1a.
Department of Infectious Diseases，Academy of Medical Sciences，General Hospital of Ningxia Medical University，Yinchuan 750000，China
1b.
Department of Surgery，Academy of Medical Sciences，General Hospital of Ningxia Medical University，Yinchuan 750000，China
2.
School of Clinical Medicine，Ningxia Medical University，Yinchuan 750000，China

Research funding:

Ningxia Natural Science Foundation (2023AAC03584);

Ningxia Natural Science Foundation (2023AAC03519)

More Information

Corresponding author: DING Xiangchun， 13619511758@163.com （ORCID： 0000-0003-0283-9419）

摘要

摘要: 肝纤维化是一种由病毒感染、酒精、化学物质等原因导致的慢性肝损伤的愈合反应，是慢性肝脏疾病进展为肝硬化和肝癌的关键环节。肝巨噬细胞被认为是肝损伤和修复的重要介质，巨噬细胞极化趋向对肝纤维化具有双向调控作用。本文阐述不同表型的肝巨噬细胞在肝纤维化发生发展过程中的作用，以期为纤维化的防治研究提供新思路。
- 肝纤维化 /
- 巨噬细胞 /
- 细胞极化
Abstract: Liver fibrosis is the healing reaction of chronic liver injury caused by various factors such as viral infection， alcohol， and chemical substances and is a key link in the progression of chronic liver diseases to liver cirrhosis and liver cancer. Liver macrophages are considered important mediators of liver injury and repair， and the polarization trend of macrophages has a bidirectional regulatory effect on liver fibrosis. This article reviews the role of different phenotypes of liver macrophages in the development and progression of liver fibrosis， in order to provide new ideas for the prevention and treatment of fibrosis.
- Liver Fibrosis /
- Macrophages /
- Cell Polarization

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图 1 巨噬细胞极化在肝纤维化中的调控作用机制

Figure 1. The regulatory mechanism of macrophage polarization in liver fibrosis

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