磁共振质子密度脂肪分数（MRI-PDFF）在肝脂肪定量中的应用

杨晨; 余上海; 徐飞鹏; 张华

doi:10.12449/JCH240327

磁共振质子密度脂肪分数（MRI-PDFF）在肝脂肪定量中的应用

DOI: 10.12449/JCH240327

杨晨¹,
余上海¹,
徐飞鹏¹,
张华^{1, 2, , ,}

1.
上海中医药大学附属曙光医院肝硬化科，上海中医药大学肝病研究所，上海 201203
2.
肝肾疾病病证教育部重点实验室，上海 201203

基金项目:

2019年度上海市科学技术委员会“科技创新行动计划”临床医学领域科技支撑项目 (19401972700)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：张华、杨晨负责课题设计，撰写论文；杨晨、余上海、徐飞鹏参与查阅文献，撰写论文初稿，修改论文；张华负责拟定写作思路，指导撰写文章并最后定稿。

详细信息

通信作者:
张华， lnutcmzh@126.com （ORCID： 0000-0001-5926-0999）

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出版历程
- 收稿日期: 2023-08-08
- 录用日期: 2023-08-28
- 出版日期: 2024-03-20

Application of magnetic resonance imaging-proton density fat fraction in liver fat quantification

Chen YANG¹,
Shanghai YU¹,
Feipeng XU¹,
Hua ZHANG^{1, 2
, ,
,}

1.
Department of Liver Cirrhosis，Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine/Institute of Liver Diseases，Shanghai University of Traditional Chinese Medicine，Shanghai 201203，China
2.
Key Laboratory of Liver and Kidney Diseases，Ministry of Education，Shanghai 201203，China

Research funding:

Shanghai Municipal Science and Technology Commission 2019 “Science and Technology Innovation Action Plan” （Clinical Medicine） (19401972700)

More Information

Corresponding author: ZHANG Hua， lnutcmzh@126.com （ORCID： 0000-0001-5926-0999）

摘要

摘要: 不同病因的慢性肝病均可出现肝脂肪变性。引起肝脂肪性病变的主要诱因包括慢性病毒性肝炎、胆汁淤积性肝病、酒精和非酒精性脂肪性肝病等。肝脂肪变性初期表现为单纯性脂肪性肝病，继而出现脂肪性肝炎、肝纤维化、肝硬化，甚至肝细胞癌。随着医学影像技术的发展，磁共振质子密度脂肪分数（MRI-PDFF）已在临床广泛应用于脂肪性肝病（FLD）的诊断。MRI-PDFF因具有精确性高及可重复性好的优点，逐步成为FLD无创诊断的“金标准”。本文对MRI-PDFF在肝脂肪定量中的临床应用及研究进展进行综述。
- 脂肪肝 /
- 磁共振成像 /
- 质子密度脂肪分数 /
- 诊断
Abstract: Hepatic steatosis can be observed in chronic liver diseases of different etiologies. The main predisposing factors for hepatic steatosis include chronic viral hepatitis， cholestatic liver disease， alcoholic liver disease， and nonalcoholic fatty liver disease. Simple fatty liver disease is the initial manifestation of hepatic steatosis， followed by steatohepatitis， liver fibrosis， liver cirrhosis， and even hepatocellular carcinoma. With the development of medical imaging technology， magnetic resonance imaging-proton density fat fraction （MRI-PDFF） has been widely used in the diagnosis of fatty liver disease （FLD） in clinical practice. MRI-PDFF is gradually becoming the gold standard for the noninvasive diagnosis of FLD due to its high accuracy and good repeatability. This article reviews the clinical application of MRI-PDFF in liver fat quantification and related research advances.
- Fatty Liver /
- Magnetic Resonance Imaging /
- Proton Density Fat Fraction /
- Diagnosis

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参考文献(46)

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