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慢性HBV感染与代谢功能障碍的流行病学与临床转归

黄娇凤 郑琦

引用本文:
Citation:

慢性HBV感染与代谢功能障碍的流行病学与临床转归

DOI: 10.12449/JCH240303
基金项目: 

国家自然基金青年科学基金项目 (82300652)

福建省自然科学基金 (2022J01700)

福建省肝病与肠道疾病临床医学研究中心 (2021Y2006)

利益冲突声明:本文不存在任何利益冲突。
作者贡献声明:黄娇凤负责撰写论文;郑琦负责指导、修改及审阅论文。
详细信息
    通信作者:

    郑琦, bei0825@163.com (ORCID: 0000-0001-8006-7069)

Epidemiology and clinical outcome of chronic hepatitis B virus infection and metabolic dysfunction

Research funding: 

National Natural Science Foundation of China Young Scientist Fund (82300652);

Natural Science Foundation of Fujian Province (2022J01700);

Clinical Research Center for Liver and Intestinal Diseases of Fujian Province (2021Y2006)

More Information
    Corresponding author: ZHENG Qi, bei0825@163.com (ORCID: 0000-0001-8006-7069 )
  • 摘要: 慢性HBV感染是一种全球性公共卫生问题,是我国肝纤维化、肝硬化、肝衰竭及原发性肝癌的主要原因。随着人们生活水平的提高及饮食结构的改变,非酒精性脂肪性肝病(NAFLD)发病率也逐渐升高。基于人群的研究发现HBV感染可影响NAFLD的发生,其中机制仍不明确。肝脂肪变性也会影响HBV血清病原学标志物的表达,合并NAFLD或其他代谢功能障碍会增加HBV感染者肝纤维化、肝硬化及肝癌的风险。慢性HBV感染与代谢障碍密切相关,未来需要更多研究进一步阐明相关机制,为临床诊疗提供理论依据。

     

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