线粒体自噬在肝脏相关疾病发生发展中的作用

潘萌; 史晓燕

doi:10.12449/JCH240232

线粒体自噬在肝脏相关疾病发生发展中的作用

DOI: 10.12449/JCH240232

潘萌,
史晓燕^, ,

陕西中医药大学基础医学院，陕西咸阳 712046

基金项目:

国家自然科学基金青年科学基金项目 (81704073);

陕西省科技厅重点研发计划一般项目 (2022SF-225)

利益冲突声明：本文不存在任何利益冲突。

作者贡献声明：潘萌负责设计论文框架，起草论文；史晓燕负责拟定写作思路，指导文章修改与定稿。

详细信息

通信作者:
史晓燕， biosalome@163.com （ORCID： 0009-0007-8350-0826）

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- 被引次数: 0
出版历程
- 收稿日期: 2023-05-14
- 录用日期: 2023-06-16
- 出版日期: 2024-02-19

Role of mitophagy in the development and progression of liver-related diseases

Meng PAN,
Xiaoyan SHI^{,
,}

Basic Medical Academy，Shaanxi University of Chinese Medicine，Xianyang，Shaanxi 712046，China

Research funding:

National Natural Science Foundation of China Youth Science Foundation Project (81704073);

General Projects of Key R & D Program of Science and Technology Department of Shaanxi Province (2022SF-225)

More Information

Corresponding author: SHI Xiaoyan， biosalome@163.com （ORCID： 0009-0007-8350-0826）

摘要

摘要: 线粒体自噬是细胞在营养缺乏或受到外界刺激时，通过对受损线粒体的特异性清除，来维持线粒体功能完整性和细胞稳态的选择性自噬。近年来，大量研究证明线粒体自噬功能失调与非酒精性脂肪性肝病、药物性肝损伤、病毒性肝炎和肝细胞癌等多种肝脏相关疾病的发生发展密切相关。本文通过对线粒体自噬调控肝脏相关疾病的具体机制进行总结，进一步阐述了线粒体自噬在肝脏相关疾病中的潜在治疗靶点，以期为肝病的临床治疗提供更为有效的策略。
- 肝疾病 /
- 线粒体自噬 /
- 病理过程
Abstract: Mitophagy is a type of selective autophagy during which cells specifically remove damaged mitochondria in response to nutrient deficiency or external stimulation and thus maintain the integrity of mitochondrial function and cellular homeostasis. In recent years， a large number of studies have shown that dysfunction of mitophagy is closely associated with the development and progression of various liver-related diseases such as nonalcoholic fatty liver disease， drug-related liver injury， viral hepatitis， and hepatocellular carcinoma. This article summarizes the specific mechanisms of mitophagy in regulating liver-related diseases and further elaborates on the potential therapeutic targets of mitophagy in liver-related diseases， in order to provide more effective therapeutic strategies for the clinical treatment of liver diseases.
- Liver Diseases /
- Mitophagy /
- Pathologic Processes

HTML全文

图 1 线粒体自噬的调控机制

注： NIX，NIP3样蛋白X。

Figure 1. Regulatory mechanisms of mitophagy

下载: 全尺寸图片幻灯片

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